Investigation of neutrophil-to-lymphocyte ratio and red cell distribution width in sudden senseurineural hearing loss

Authors

  • Caner Sahin Department of Medicine, Alanya Alaattin Keykubat University, Faculty of Medicine, ENT Clinic, Antalya, Turkey
  • Ceyhun Varıim Department of Internal Medicine, Sakarya University, Faculty of Medicine, Sakarya, Turkey
  • Cengiz Karacaer Department of Internal Medicine, Sakarya University, Faculty of Medicine, Sakarya, Turkey

DOI:

https://doi.org/10.18203/2349-3933.ijam20191153

Keywords:

Neutrophil to lymphocyte ratio, Red cell distribution width, Sudden hearing loss

Abstract

Background: Sudden hearing loss (DHL) is a sudden sensorineural hearing loss effecting et least 3 or more frequencies more than 30 Decibel. The purpose of this study was to investigate the usefulness of the neutrophil to lymphocyte ratio (NLR) and Red Cell Distribution Width (RDW) in the first diagnosis of sudden sensorineural hearing loss (SSHL).

Methods: Total 24 patients diagnosed with SSHL and 24 control patients included in the study. Serum samples were analyzed retrospectively on the initial presentation.

Results: On admission, the NLR was 2.1±1.1 The mean absolute neutrophil count was 7100±400/mm3, and the mean complete lymphocyte count was 3400±1100/mm3. RDW was 11.9±0.6. Eight patients had total healing, 12 patients had partial cure, and two patients had no healing in the study. Statistically significant changes in NLR determined in the measurements between SSHL and control group (p<0.05). Significant differences were not observed in hemoglobin and hematocrit values, lymphocyte counts, RDW measurements between SSHL and control group (p <0.05).

Conclusions: In lights of this information we recommend to screen NLR levels in SSHL patients. This may help us follow up patients recovery and if the patients recover from the disease higher level of NLR may create doubt for recurrence of the disease in risky patients.

References

Sara SA, Teh BM, Friedland P. Bilateral sudden sensorineural hearing loss: review J Laryngol Otol. 2014;(128 Suppl)1:8-15.

Abdel-Razik A, Mousa N, Besheer TA, Eissa M, Elhelaly R, Arafa M, et al. Neutrophil to lymphocyte ratio as a reliable marker to predict insulin resistance and fibrosis stage in chronic hepatitis C virus infection. Acta Gastroenterol Belg. 2015;78(4):386-92.

Wang F, Hu S, Ding Y, Ju X, Wang L, Lu Q, Wu X. Neutrophil-to-Lymphocyte Ratio and 30-Day Mortality in Patients with Acute Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis. 2016;25(1):182-7.

Kurtul S, Sarli B, Baktir AO, Demirbas M, Saglam H, Dogan Y, et al. Neutrophil to lymphocyte ratio predicts SYNTAX score in patients with non-ST segment elevation myocardial infarction. Int Heart J. 2015;56(1):18-21.

Danese E, Lippi G, Montagnana M. Red blood cell distribution width and cardiovascular diseases. J Thorac Dis. 2015;7(10):402-11.

Altun I, Akin F, Kose N, Sahin C, Kirli I. Predictors of slow flow in angiographically normal coronary arteries. Int J Clin Exp Med. 2015 15;8(8):3762-8.

Furer A, Finkelstein A, Halkin A, Revivo M, Zuzut M, Berliner S, et al. High red blood cell distribution width and preclinical carotid atherosclerosis. Biomarkers. 2015 Oct 3;20(6-7):376-81.

İkincioğulları AK, Kılıç M, Atan D, Özcan KM, Çetin MA, Ensari S. New inflammation parameters in sudden sensorineural hearing loss: neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Int Adv Otol. 2014 Oct 1;10(3):197-200.

Ozler GS. Increased neutrophil-lymphocyte ratio in patients with idiopathic sudden sensorineural hearing loss. J Craniofac Surg. 2014;25(3):260-3.

Seo YJ, Park YA, Bong JP, Park DJ, Park SY. Predictive value of neutrophil to lymphocyte ratio in first-time and recurrent idiopathic sudden sensorineural hearing loss. Auris Nasus Larynx. 2015;42(6):438-42.

Seo YJ, Jeong JH, Choi JY, Moon IS. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis inpatients with idiopathic sudden sensorineural hearing loss. Dis Markers. 2014;2014:702807.

Ulu S, Ulu MS, Bucak A, Ahsen A, Yucedag F, Aycicek A. Neutrophil-to-lymphocyte ratio as a new, quick, and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2013;34(8):1400-4.

Yčas JW, Horrow JC, Horne BD. Persistent increase in red cell size distribution width after acute diseases: A biomarker of hypoxemia?. Clin Chimi Acta. 2015 Aug 25;448:107-17.

Freeman SR, Bray ME, Amos CS, Gibson WP. The association of codeine, macrocytosis and bilateral sudden or rapidly progressive profound sensorineural deafness. Acta Otolaryngol. 2009;129(10):1061-6.

Tseliou EL, Terrovitis JV, Kaldara EE, Ntalianis AS, Repasos E, Katsaros LA, et al. Red blood cell distribution width is a significant prognostic marker in advanced heart failure, independent of hemoglobin levels. Hellenic J Cardiol. 2014 Nov 1;55(6):457-61.

Xi Q, Liu Z, Zhao Z, Luo Q. Red blood cell distribution width predicts responsiveness of acute pulmonary vasodilator testing in patients with idiopathic pulmonary arterial hypertension. Clin Chim Acta. 2015 15;446:272-6.

Kara H, Degirmenci S, Bayir A, Ak A, Akinci M, Dogru A, et al. Red cell distribution width and neurological scoring systems in acute stroke patients. Neuropsychiatr Dis Treatment. 2015;11:733-9.

Ipek S, Cekic C, Alper E, Coban E, Eliacik E, Arabul M, et al. Can red cell distribution width be a marker of disease activity in ulcerative colitis?. Int J Clin Experimental Med. 2015;8(8):13848.

Akboga MK, Abacı A, Canpolat U, Yayla C, Sahinarslan A, Açıkgöz K, et al. Association of red blood cell distribution width with presence and severity of rheumatic mitral valve stenosis. Arch Turkish Soc Cardiol. 2015 Apr 1;43(3):227-33.

Sahin C, Varım C Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, Mean Platelet Volume and Red Cell Distribution Width Measures in Bells Palsy. Open Access Maced J Med Sci. 2017 Mar 15;5(1):14-8.

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Published

2019-03-25

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Original Research Articles