A cross sectional study of cutaneous manifestations in 300 patients of diabetes mellitus

Authors

  • Sandeep Khuraiya Department of Dermatology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
  • Nancy Lal Department of Radiation Oncology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
  • Naseerudin . Department of Dermatology, Dr. SNMC, Jodhpur, Rajasthan, India
  • Vinod Jain Department of Dermatology, Dr. SNMC, Jodhpur, Rajasthan, India
  • Dilip Kachhawa Department of Dermatology, Dr. SNMC, Jodhpur, Rajasthan, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20190122

Keywords:

Cutaneous manifestations, Diabetes mellitus, Glycosylated hemoglobin

Abstract

Background: Diabetes Mellitus (DM) is a worldwide problem and one of the most common endocrine disorder. The skin is affected by both the acute metabolic derangements and the chronic degenerative complications of diabetes.

Methods: The present study was a one-year cross sectional study from January 2014 to December 2014. All confirmed cases of DM with cutaneous manifestations irrespective of age, sex, duration of illness and associated diseases, willing to participate in the study were included in the study. Routine haematological and urine investigations, FBS, RBS and HbA1c levels were carried out in all patients.

Results: A total of 300 patients of diabetes mellitus with cutaneous manifestations were studied. Majority belonged to the 4th decade (33%) and 3rd decade (27.7%) respectively. Males constituted 65% of the cases and male to female ratio was 1.85:1. Type 2 DM was most commonly observed (96%). Among the 300 diabetic patients, 73 patients (24.3%) had good control of DM with HbA1c levels in the range of 6.5-7% while 132 patients (44%) had a poor control of DM with HbA1c levels >8%. Hypertension was the most commonly associated systemic illness (37.6%). Cutaneous infections (63%) were the most commonly observed manifestation of which fungal infections (35.3%) were most frequently observed. Some of the other dermatoses observed were generalized pruritus (15.3%), acrochordons (11%), acanthosis nigricans (6%), diabetic dermopathy (5.33%), diabetic foot (3%), peripheral vascular disease (2.66%), vitiligo (2.66%), xanthelasma palpebrarum (2.33%), diabetic bullae (1%). Cutaneous infections, dermatoses associated with microangiopathy were more common in the uncontrolled diabetic patients which was statistically significant.

Conclusions: Infections were the most common cutaneous manifestations in diabetics followed by dermatoses most commonly associated with diabetes. Proper skin care and long-term control of blood glucose levels may reduce the risk of some of the skin diseases.

References

Centers for Disease Control and Prevention, 2011 National Diabetes. Available from http://www.cdc.gov/DIABETES//pubs/factsheet11.htm. Accessed 25 August 2013.

Sibbald RG, Schacter RK. The skin and diabetes mellitus. Inter J Dermatol. 1984;23(9):567-84.

Ciccone MM, Scicchitano P, Cameli M, Cecere A, Mattioli AV. Endothelial function in pre-diabetes, diabetes and diabetic cardiomyopathy: a review. J Diab Metab. 2014;5:1-0.

Mahajan S, Koranne RV, Sharma SK. Cutaneous manifestation of diabetes melitus. Ind J Dermatol Venereol Leprol. 2003;69(2):105.

Nigam PK, Pande S. Pattern of dermatoses in diabetics. Ind J Dermatol, Venereol Leprol. 2003;69(2):83.

Sawhney MP, Talwar OP, Tutakne MA, Rajpathak SD. Diabetic dermoangiopathy: a clinicopatho-logical correlation. Ind J Dermatol Venereol Leprol. 1992;58(3):173.

Rao GS, Pai GS. Cutaneous manifestations of diabetes mellitus. Ind J Dermatol Venereol Leprol. 1997;63(4):232-4.

Bhat YJ, Gupta V, Kudyar RP. Cutaneous manifestations of diabetes mellitus. Int J Diab Dev Ctries. 2006;26(4):153.

Ragunatha S, Anitha B, Inamadar AC, Palit A, Devarmani SS. Cutaneous disorders in 500 diabetic patients attending diabetic clinic. Ind J Dermatol. 2011;56(2):160.

Al-Mutairi N, Zaki A, Sharma AK, Al-Sheltawi M. Cutaneous manifestations of diabetes mellitus. Med Principles Prac. 2006;15(6):427-30.

Paron NG, Lambert PW. Cutaneous manifestations of diabetes mellitus. Primary Care: Clin Office Prac. 2000;27(2):371-83.

Goyal A, Raina S, Kaushal SS, Mahajan V, Sharma NL. Pattern of cutaneous manifestations in diabetes mellitus. Ind J Dermatol. 2010;55(1):39.

Chatterjee N, Chattopadhyay C, Sengupta N, Das C, Sarma N, Pal SK. An observational study of cutaneous manifestations in diabetes mellitus in a tertiary care hospital of Eastern India. Ind J Endocrinol Metab. 2014;18(2):217.

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Published

2019-01-23

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Original Research Articles