Evaluation of the lipid parameters in chronic heart failure patients and their correlation with body mass index

Authors

  • Rohit Sane Department of Research and Development, Madhavbaug Hospital, Khopoli, Maharashtra, India
  • Gurudatta Amin Department of Clinical Operations, Madhavbaug Hospital, Khopoli, Maharashtra, India
  • Snehal Dongre Medical Head, Madhavbaug Hospital, Khopoli, Maharashtra, India
  • Rahul Mandole Department of Research and Development, Madhavbaug Hospital, Khopoli, Maharashtra, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20192243

Keywords:

Body mass Index, Dyslipidemia, Lipid profile, Obesity

Abstract

Background: Increased body mass index (BMI) is associated with dyslipidemia, but relevant data in patients with cardiac morbidity is scarce. This study assessed lipid parameters in chronic heart failure (CHF) patients and their statistical correlation with BMI.

Methods: The retrospective study utilized data of CHF patients who visited Madhavbaug clinics in India between July-December 2018. Serum lipid profile noted were total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL), high-density lipoproteins (HDL) and very low-density lipoproteins (VLDL). Patients were classified based on BMI (normal, overweight, obese) and their mean lipid parameters were compared.

Results: Out of 147 patients, 74.15% were males with mean age 59.15±10.28 years and mean BMI 26.69±4.97 kg/m2. 56 patients had normal BMI, 60 were overweight and 30 were obese. Mean TC, TG and LDL levels in the normal-BMI group were significantly lower than that in overweight and obese groups (p<0.05). Mean HDL and VLDL were found to be higher in overweight group as compared to that in normal-BMI and obese group (p<0.05). Weak positive correlations were found between BMI and TC (R=0.09, p>0.05), BMI and TG (R=0.07, p>0.05), BMI and LDL (R=0.09, p>0.05) as well as BMI and VLDL (R=0.02, p>0.05). There was inverse correlation seen between BMI and HDL (R=-0.12, p>0.05).

Conclusions: Increase in BMI was associated with dyslipidemia in CHF patients. There was positive correlation of BMI with LDL, TG, TC as well as VLDL while there was negative correlation between BMI and HDL levels. Obesity may increase the dyslipidemia risk in CHF patients which may affect their prognosis.

References

Prabhakaran D, Jeemon P, Roy A. Cardiovascular Diseases in India. Circulation. 2016;133(16):1605-20.

Coronel R, de Groot JR, van Lieshout JJ. Defining heart failure. Cardiovasc Res. 2001; 50(3):419-22.

Misra A, Khurana L. Obesity and the metabolic syndrome in developing countries. J Clin Endocrinol Metab. 2008;93(11 Suppl 1):S9-30.

Kenchaiah S, Evans JC, Levy D. Obesity and the risk of heart failure. New Engl J Med. 2002;347(5):305-13.

Gierach M, Gierach J, Ewertowska M, Arndt A, Junik R. Correlation between Body Mass Index and Waist Circumference in Patients with Metabolic Syndrome. ISRN Endocrinol. 2014;2014:514589.

Joshi SR, Anjana RM, Deepa M, Pradeepa R, Bhansali A, Dhandania VK, et al. Prevalence of Dyslipidemia in Urban and Rural India: The ICMR-INDIAB Study. PLoS One. 2014;9(5): e96808.

The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAMA. 1984 Jan 20;251(3):351-64.

National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002 Dec 17;106(25):3143-421.

Ranganathan S, Krishnan TU, Radhakrishnan S. Comparison of dyslipidemia among the normal-BMI and high-BMI group of people of rural Tamil Nadu. Med J DY Patil Univ. 2015;8(2):149-52.

Archana, Agarwal V, Ahmad N, Gupta A. Study of body mass index (BMI) and serum lipid profile of patients at a tertiary hospital: a cross sectional study. Int J Res Med Sci. 2018;6(6):2060-2.

Cha E, Akazawa MK, Kim KH, Dawkins CR, Lerner HM, Umpierrez G, et al. Lifestyle habits and obesity progression in overweight and obese American young adults: Lessons for promoting cardiometabolic health. Nurs Health Sci. 2015;17(4):467-75.

Gillespie CD, Keenan NL, Miner JB, Hong Y. Division for heart disease and stroke prevention, national center for chronic disease prevention and health promotion. MMWR Surveill Summ. 2012;61(2):26-31.

Zaman GS. Influence of lifestyle patterns on perceptions of obesity and overweight among expatriates in Abha city of Kingdom of Saudi Arabia. J Nat Sci Biol Med. 2015;6(2):329-34.

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Published

2019-05-24

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Original Research Articles