DOI: http://dx.doi.org/10.18203/2349-3933.ijam20194208

Prevalence of impaired glucose tolerance in different grades of obesity

Jitendra Kumar Rai, J. L. Wadhwani, Manuj Sharma, T. N. Dubey

Abstract


Background: Surgical Background: Impaired glucose tolerance is known precursor of type-2 diabetes mellitus and more prevalent in obese people, different studies have varied results and true prevalence is still debatable. Aims of this study  to investigate the prevalence of IGT in different grades of obesity.

Methods: Authors have studied100 patients with obesity Grade1 (BMI >25 kg/m2 but <30) and Grade2 (BMI >30 kg/m2) at Gandhi Medical College, Bhopal during April to June 2019. Complete physical examination and blood tests including fasting blood glucose and oral glucose tolerance test (OGTT) were done.

Results: Results shows that 16% male and 14% female subjects had IGT. Male of age more than 60yrs and female aged between 51 to 60 were more pre-diabetic. Males having weight 71 to 80 kg and female of 51-60 kg were more pre-diabetic. Subjects with grade 1 obesity, 6.12% male and 5.88% female had IGT. Similarly, in grade 2-obese subjects 10.20% males and 7.84% females had IGT.

Conclusion: IGT is more prevalent in grade-1 and grade-2 obese population and a strong indicator of diabetes.


Keywords


Body mass index, Impaired glucose tolerance, Pre-diabetes

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References


Cook MB, Freedman ND, Gamborg M, Sørensen TI, Baker JL. Childhood body mass index in relation to future risk of oesophageal adenocarcinoma. Br J Cancer. 2015;112(3):601-7.

Padmini B, Kamalamma N, Patel TG. A Community-Based Diabetes Prevention and Management Education Programme in a Rural Village in India. Diabetes Care. 2008;31(6):1097-104.

World Health Organization Definition and Diagnosis of Diabetes mellitus and Intermediate Hyperglycemia: Report of a WHO/IDF Consultation. 2006. Available at: https://www.who.int/diabetes/publications/Definition%20and%20diagnosis%20of%20diabetes_new.pdf Accessed on 23 Aug 2019.

Arora S. Insulin Resistance. Rijeka, Croatia: In Tech Europe; 2012. Molecular basis of insulin resistance and its relation to metabolic syndrome. Available at: http://www.intechopen.com/books/insulin-resistance/molecular-basis-of-insulin-resistance-and-its-relation-to-metabolic-syndrome. Accessed on 12 June 2019.

Coutinho M, Gerstein HC, Wang Y. The relationship between glucose and incident cardiovascular events. A met regression analysis published data from20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care. 1999;22(2):233-40.

Choudhary K, Mathur P, Garg M, Gupta P. Prevalence of impaired glucose tolerance test and diabetes in overweight, obese and apparently healthy school going adolescents. Int J Contemp Pediatr. 2017:1081-7.

Sinha R, Fisch G, Teague B, William RN, Banyas B, Allen K, et al. Prevalence of impaired glucosetolerance among children and adolescent with marked obesity. N Eng J Med. 2002;346:802-10.

Dunstan DW, Zimmet PZ, Welborn TA, De Courten MP, Cameron AJ, Sicree RA, et al. The Rising Prevalence of Diabetes and Impaired Glucose Tolerance. Diabetes Care. May 2002, 25(5)829-34.

Malini DS, Sahu A, Mohapatro S, Tripathy R. Assessment of Risk Factors for Development of Type-II Diabetes Mellitus Among Working Women in Berhampur, Orissa. Indian J Community Med. 2009;34(3):232-6.

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus: The Diabetes Control and Complications Trial Research Group. N Engl J Med. 1993;329(14):977-86.