DOI: http://dx.doi.org/10.18203/2349-3933.ijam20195236

Clinical patterns and outcome of acute poisoning at a tertiary care hospital in coastal Karnataka, India

Akshatha Rao Aroor, Rama Prakasha Bhat Saya, Sucharitha Suresh

Abstract


Background: Periodic epidemiological studies are necessary to analyse the patterns of poisoning in each region. The aim of this study was to characterise the acute poisoning cases admitted to a tertiary care centre in coastal Karnataka.

Methods: All the adult patients admitted to the emergency department of the hospital during the past five years were included. Data was obtained from the hospital medical records and included socio-demographic characteristics, causative agents, mode of poisoning, route of poisoning, time of arrival to the hospital and factors determining mortality.

Results: Of the 169 patients admitted with acute poisoning, majority belonged to young age group (46.7%) and were females (50.9%). Poisoning was more common among the, married population (59.2%) and literates (62.7%). Clustering of cases were found during summer (36.7%) and monsoon (35.5%). Ingestion was the commonest route (98.2%) and the intention was suicidal (82.2%) in majority of the patients. Drug overdose (49.1%) was the commonest agent followed by pesticides (14.8%) and rodenticides (12.4%). Acetaminophen and antipsychotic drugs were the commonly used drugs. Psychiatric illness was found in a significant number of patients (37.9%). The most common symptom was nausea and vomiting (40.2%). Mortality was seen in 7.7% of the patients. Factors contributing to mortality were male gender, intake of pesticides, renal failure and Acute Respiratory Distress Syndrome (ARDS).

Conclusions: There is an increase in the number of cases abusing drugs and medications. There is an urgent need to address the susceptive young population and patients with underlying psychiatric illness to reduce the number of poisoning cases in this region.


Keywords


Acute poisoning, Drugs, Pesticides

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References


World Health Organization. Fact sheet: Poisoning Prevention and Management, 2012. Available at: http://www.who.int/ipcs/poisons/en/. Accessed 11 September 2019.

World Health Organisation. Fact sheet: International Programme on Chemical Safety, 1997. Available at: http://www.who.int/ipcs/publications/training poisons/guidelines poison control/en/. Accessed 11 September 2019.

Batra AK, Keoliya AN, Jadhav GU. Poisoning: an unnatural cause of morbidity and mortality in rural India. J Assoc Physi Ind. 2003;51:955-9.

Kishi M. International pesticide use. Introduction. Int J Occup Environ Health. 2001;7(4):259-65.

Jeyaratnam J. Acute pesticide poisoning: a major global health problem. World Health Stat Q. 1990;43:139-44.

Ramesha KN, Rao KB, Kumar GS. Pattern and outcome of acute poisoning cases in a tertiary care hospital in Karnataka, India. Ind J Crit Care Med: peer-rev, Offic Pub Ind Soci Crit Care Medi. 2009;13(3):152.

Jaiprakash H, Sarala N, Venkatarathnamma PN, Kumar TN. Analysis of different types of poisoning in a tertiary care hospital in rural South India. Food Chem Toxicol. 2011;49(1):248-50.

Murari A, Sharma GK. A comparative study of poisoning cases autopsied in LHMC, New Delhi and JIPMER Pondicherry. J For Medi Toxicol. 2002;19(1):18-20.

Singh D, Jit I, Tyagi S. Changing trends in acute poisoning in Chandigarh zone: a 25-year autopsy experience from a tertiary care hospital in northern India. Am J for Medi Pathol. 1999;20(2):203-10.

Singh B, Unnikrishnan B. A profile of acute poisoning at Mangalore (South India). J Clin For Medi. 2006;13(3):112-6.

Muhammad R, Afridi MAR, Ali Z, Asghar M, Sebtain A, Amer K, et al. Etiological and clinical profile of patients presenting with acute poisoning to a teaching hospital. J Post Medi Inst. 2018;32(1):54-9.

Eddleston M. Patterns and problems of deliberate self‐poisoning in the developing world. Qjm. 2000;93(11):715-31.

Singh O, Javeri Y, Juneja D, Gupta M, Singh G, Dang R. Profile and outcome of patients with acute toxicity admitted in intensive care unit: Experiences from a major corporate hospital in urban India. Ind J Anaesth. 2011;55(4):370.

Santosh VC, Menon O. Retrospective Study of Clinical Profile of Acute Poisoning in a Tertiary Care Teaching Hospital in Kerala, India, during 2014-2016. Int J Sci Study. 2018;6:67-71.

Rajbanshi LK, Arjyal B, Mandal R. Clinical profile and outcome of patients with acute poisoning admitted in intensive care unit of tertiary care center in Eastern Nepal. Ind J Criticare Medi: peer-rev, Offic Pub Ind Soci Criti Care Medi. 2018;22(10):691.

Nigam M, Jain AK, Dubey BP, Sharma VK. Trends of organophosphorus poisoning in Bhopal region an autopsy based study. J Ind Acade For Medi. 2004;26(2):62-5.

Chintale KN, Patne SV, Chavan SS. Clinical profile of organophosphorus poisoning patients at rural tertiary health care centre. Int J Adv Med. 2016 Apr;3(2):268-74.

Sarkar D, Shaheduzzaman M, Hossain MI, Ahmed M, Mohammad N, Basher A. Spectrum of acute pharmaceutical and chemical poisoning in northern Bangladesh. Asia Paci J Medi Toxicol. 2013;2(1):2-5.

Dash SK, Raju AS, Mohanty MK, Patnaik KK, Mohanty S. Sociodemographic profile of poisoning cases. J Indi Acade For Medi. 2005;27(3):133-8.

Patil A, Peddawad R, Verma VC, Gandhi H. Profile of acute poisoning cases treated in a tertiary care hospital: A Study in Navi Mumbai. Asia Paci J Medi Toxicol. 2014;3(1):36-40.

Ahuja H, Mathai AS, Pannu A, Arora R. Acute poisonings admitted to a tertiary level intensive care unit in northern India: patient profile and outcomes. J Clini Dia Res: JCDR. 2015 Oct;9(10):UC01.

Padmanabha TS, Gumma K, Kulkarni GP. Study of profile of organophosphorus poisoning cases in a tertiary care hospital, North Karnataka, Bidar, India. Int J Pharm Bio Sci. 2014;5(1):332-9.