DOI: http://dx.doi.org/10.18203/2349-3933.ijam20195654

Clinical study of cardiovascular involvement in patients with hypothyroidism

U. Kishan, J. Gopala Krishna

Abstract


Background: Hypothyroidism is usually associated with the involvement of the cardiovascular system in the form of the cardiac abnormalities. The Research data on this has been found to be limited. The dysfunction of the cardiac caused by hypothyroidism is usually reversible. Objective was to study the incidence of cardiac abnormalities in patients with hypothyroidism.

Methods: Total 40 confirmed cases of hypothyroid disease were included in the present study. General investigations, ECG, ECHO was done in all the patients to assess for cardiovascular involvement. The data was entered in the Microsoft Excel worksheet and analysed using proportions.

Results: One fourth of the patients were found to have the bradycardia. The Delayed ankle jerk was seen in 67.5% of the cases and the next common CNS manifestation was the hoarseness of the voice. 30% of the case had normal ECG findings. 40% of the cases had the bradycardia. 35% of the cases had the low voltage complexes. 32.5% of the cases had the normal ECHO reports. 27.5% of the cases had the pericardial effusion. Same proportion of the cases were found to have the diastolic dysfunction. But most of them had the dysfunction and the severe cases were found to be very few. Only two patients had IVS thickness.

Conclusions: Majority of the cases of the hypothyroidism in the present study were found to have the cardiovascular involvement. This points towards the importance of the early diagnosis of hypothyroidism and the prevention of complications like the cardiovascular system and the central nervous system involvement.

Keywords


Diastolic dysfunction, Electrocardiogram, Echocardiogram, Hypothyroidism, Low-density lipoproteins, Pericardial effusion

Full Text:

PDF

References


Larry Jameson J, Mandel SJ, Weetman AP. Disorders of thyroid gland. In: Kasper D, Fauci A, Hauser S et al, eds. Harrisons Principles of Internal Medicine, 19th ed. McGraw-Hill; 2011:2283-2308.

Rawat B, Satyal A. An echocardiographic study of cardiac changes in hypothyroidism and the response to treatment. Kathmandu Univer Med J (KUMJ). 2004;2(3):182-7.

Buccino RA, Spann JF, Pool PE, Sonnenblick EH, Braunwald E. Influence of the thyroid state on the intrinsic contractile properties and energy stores of the myocardium. J Clin Investig. 1967 Oct 1;46(10):1669-82.

Nikoo MH. Cardiovascular manifestations in hypothyroidism. SEMJ. 2001;42(2):42-5

Ladenson PW. Recognition and management of cardiovascular disease related to thyroid dysfunction. Am J Med. 1990 Jun 1;88(6):638-41.

Zwillich CW, Pierson DJ, Hofeldt FD, Lufkin EG, Weil JV. Ventilatory control in myxedema and hypothyroidism. New Engl J Med. 1975 Mar 27;292(13):662-5.

Bough EW, Crowly WF. Myocardial function in hypothyroidism. Arch Intern Med. 1978;138(10):1476-80.

Lambert EH, Underdahl LO, Beckett S, Mederos LO. A study of the ankle jerk in myxedema. J Clin Endocrinol. 1951 Oct 1;11(10):1186-205.

Verma R. Heart in hypothyroidism. J Assoc Phys Ind. 1996;44:390-3.

Forfar JC, Muir AL, Toft AD. Left ventricular function in hypothyroidism. Responses to exercise and beta adrenoceptor blockade. Heart. 1982 Sep 1;48(3):278-84.