Carcinosarcoma of ovary - a rare case report and literature overview

Niroopama Pushpagiri, Shanthi Dinakaran, Alagamai Chidambaram, Priya Pari


Ovarian carcinosarcoma is one of the lethal malignant tumours of the female genital system. It is extremely rare and represents 1% of all malignant ovarian tumours. It occurs most commonly in postmenopausal women with the incidence peak in sixth decade. Our reported case was a 41 years nulliparous lady who presented with abdominal distension for one month. Physical examination revealed a huge non tender abdomino-pelvic mass suspected to be of ovarian origin. She was investigated and radiological studies confirmed a left ovarian cystic mass of 26 cm x 22 cms with solid enhancement. Calculated RMI was 66. Staging laparotomy was performed and tense smooth surface cystic mass arising from left ovary was found and removed intact. Total abdominal hysterectomy, salpingo-oophorectomy, infracolic omentectomy was done along with the peritoneal, lymph node biopsies and peritoneal washings for cytology. The presentation and findings were indistinguishable from epithelial ovarian neoplasm. Histo-pathology revealed carcinosarcoma of ovary with positive peritoneal cytology. Staged as IC according to FIGO criteria. The patient was given 6 cycles of adjuvant chemotherapy with carboplatin and ifosfamide and was in good health at the time of follow up visits.


Ovarian carcinosarcoma, Staging laparotomy, Adjuvant chemotherapy

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Harris MA, DelAP LM, Sengupta PS, Wilkinson PM, Welch RS, Swindell R et al. Carcinosarcom of the ovary. Br. J Cancer. 2003;88(5):654-7.

Mark E. Mullins, Steven Chao, Erin R. Ochoa and Priscilla J. Slanetz. Ovarian Carcinoma. Am J Roentgenol. 2001;177:130-130.

Chang J, Sharpe J, A’Hern RP, Fisher C, Blake P,Shepherd J, Gore M. Carcinosarcoma of the ovary: incidence, prognosis, treatment and survival of patients. Ann Oncol. 1995;6(8):755-8.

Brown E, Stewart M, Rye T, Al-Nafussi A, Williams AR, Bradburn M, et al. Carcinosarcoma of the ovary: 19 years of prospective data from a single center. Cancer. 2004;100(10):2148-53.

George EM, Herzog TJ, Neugut AI, Lu YS, Burke WM, Lewin SN et al. Carcinosarcoma of the ovary: natural history, patterns of treatment and outcome. Gynecol Oncol. 2013;131:42-5.

Rutldge TL, Gold MA, McMeekin DS, Huh WK, Powell MA, Lewin SN et al. Carcinosarcom of the ovary- a case series. Gynaecol Oncol. 2006;100(1):128-13.

Thigpen JBT, Blessing JA, DeGeest K, Look KY, Homesley H. Cisplatin as initial chemotherapy in ovarian carcinosarcomas: a gynecologic oncology group study. Gynecol Oncol. 2004:93(2):336-9.

Lu CH, Chen IH, Chen YJ, Wanq KL, Qlu JT, et al. Primary treatment and prognostic factors of carcinosarcoma of the ovary, fallopian tube, and peritoneum: a Taiwanese gynaecologic Oncology Group Study. Int J Gynecol Cancer. 2014;24(3): 506-12.