DOI: http://dx.doi.org/10.18203/2349-3933.ijam20201110

Study of etiological spectrum and clinical profile of patients admitted in tertiary care hospital of South Gujarat, India

Mohnish M. Patel, K. N. Bhatt, Khyati T. Jariwala

Abstract


Background: Pancytopenia is defined as reduction of all three formed elements of blood below normal reference range. The symptoms are fatigue, fever, dizziness and weight loss. Evaluation was done using complete hemogram and peripheral smear. The presenting marrow biopsy is most useful and accurate in evaluation of pancytopenia.

Methods: Two ml of anticoagulated blood was collected for complete hemogram. The peripheral blood smear was stained with Leishman's stain and studied. Bone marrow biopsy and aspiration was done in all the patients to identify etiology.

Results: Predominance was seen in the age group of 31-60 years. Most common cause of pancytopenia was megaloblastic anaemia in this study compared to other studies all over the world where most common cause was aplastic anaemia. This reflects higher prevalence of megaloblastic anaemia in the Indian subjects.

Conclusions: A comprehensive clinical, haematological land bone marrow study of patients with pancytopenia usually helps in identification of the underlying cause.


Keywords


Aplastic anaemia, Fatigue, Megaloblastic anaemia, Pancytopenia

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References


Khodke K, Marwah S, Buxi G, Yadav RB, Chaturvedi NK. Bone marrow Examination in cases of Pancytopenia. JIACM. 2001;2:55-9.

Jha A, Sayani G, Adhikari RC, Panta AD, Jha R. Bone marrow Examination in cases of Pancytopenia. JNMA. 2008 Jan-Mar:47(169):12-7.

International agranulocytosis and aplastic anaemia study. Incidence of aplastic anaemia, the relevance of diagnostic criteria. Blood. 1987;70(6):1718-21.

Imbert M, Scoazec JY, Mary JY, Jouzult H, Rochant H, Sultan C. Adult patients presenting with Pancytopenia: a reappraisal of underlying pathology and diagnostic procedures in 213 cases. Hematol Pathol. 1989;3:159-67.

Varma N, Dash S. A reappraisal of underlying pathology in adult patients presenting with Pancytopenia. Trop Geogr Med. 1992;44:322-7.

Bone Marrow examination: indication and technique. In: Anesoft, Foucar K, editors. Bone marrow pathology. Hong kong: American society Clinical Pathology; 2001:30-47.

Nanda A, Basu S, Marwaha N. Bone marrow trephine biopsy as an adjunct to bone marrow aspiration. J Assoc Physicians India. 2002;50:893-5.

Wintrobe MM. Clinical Hematology. 8th edition Philadelphia: Lea and Febiger; 1981:699-915.

Keisu M, Ost A. Diagnosis in patients with severe Pancytopenia suspected of having aplastic anaemia. Eur J Haematol. 1990;45:11-4.

Weston CF, Hall MJ. Pancytopenia and folate deficiency in alcoholics. Postgrad Med J. 1987 Feb 1;63(736):117-20.

Talarmin F, Hugard L, Mion M, Sillier P, Charles D. Vitamin deficiency Pancytopenia. Ann Med Intern (Paris). 1994;145(3):159-62.

Aziz T, Ali L, Ansari T, Liaquat HB, Shah S, Ara J. Pancytopenia: megaloblastic anemia is still the commonest cause. Pak J Med Sci. 2010 Jan 1;26(1):132-6.

Ishtiaq O, Baqai HZ, Anwer F, Hussain N. Patterns of Pancytopenia patients in a General Medical Ward and a proposed diagnostic approach. J Ayub Med Coll Abottabad. 2004;16(1):8-13.

Niazi M, Fazli-Raziq. The incidence of underlying pathology in Pancytopenia: an experience of 189 cases. J Postgrad Med Inst. 2004;18:76-9.

Kumar R, Kalra SP, Kumar H, Anand AC, Madan H. Pancytopenia--a six year study. J Assoc Physici India. 2001 Nov;49:1078-81.

Memon S, Shaikh S, Nizamani MA. Etiological spectrum of pancytopenia based on bone marrow examination in children. J Coll Physicians Surg Pak. 2008 Mar 1;18(3):163-7.

Daniel NM, Byrd S. Aplastic anaemia : an analysis of 50 cases. Ann intern Med. 1958;49:326-36.

Osama I, Baqai Hz, Anwar F, Hussain N. Patterns of Pancytopenia in a general medical ward and a proposed diagnostic approach. JAMC. 2002; 16(1):8-13.

Savage DG, Allen RH, Gangaidzo IT, Levy LM, Gwanzurn C. Pancytopenia in Zimbabwe. Am J Med Sci. 1999;317(1):22-32.