DOI: http://dx.doi.org/10.18203/2349-3933.ijam20201123

Seroprevalence of hepatitis C virus among patients at a tertiary health care centre in Rajasthan, India

Ajay Mathur, Laxmi Kant Goyal, Manoj Kumar Sharma, Arvind Kumar Gupta, Nupur Hooja, R. N. Yadav

Abstract


Background: To ascertain the prevalence of Hepatitis C infection among patients visiting a tertiary care center in Jaipur, Rajasthan.

Methods: An observation analytic study was done at a tertiary care center affiliated to Medical College with retrospective analysis of the hospital data of two calendar years. During this period HCV infection screening (anti-HCV) was offered to every suspected patient admitted in hospital and every pregnant women visiting antenatal care clinic.

Results: The study prevalence of HCV infection was 0.05% (13/25311). The prevalence was more in female (0.03%) than male (0.02%). The study prevalence of anti-HCV among pregnant female was 0.02% (3/16224). Maximum positive cases (4/13, 30.77% positive cases) were in the age group of 21-30 years (sexually active group) and >50 years age group while minimum positivity was found in children (00 case, 0-20 years age).

Conclusions: In this study, prevalence of HCV infection was 0.05%. The study prevalence of HCV among pregnant females was 0.02%. Maximum positive cases (4/13, 30.77% positive cases) were in the age group of >50 years and 21-30 years. This study aids in view to strengthen proper screening for HCV infection to reduce HCV related morbidity and mortality


Keywords


Anti- Hepatitis C virus, Hepatitis C virus infection, Pregnant female, Prevalence, Screening

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References


World Health Organization. Key Facts: Hepatitis C, July 2019. Available at https://www.who.int/news-room/fact-sheets/detail/hepatitis-c. Accessed 11 February 2020

Khaja MN, Madhavi C, Thippavazzula R, Nafeesa F, Habib AM, Habibullah CM, et al. High prevalence of hepatitis C virus infection and genotype distribution among general population, blood donors and risk groups. Infect Genet Evol. 2006;6:198-204.

Goel A, Seguy N, Aggarwal R. Burden of hepatitis C virus infection in India: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2019;34(2):321-9.

Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Int Med. 2006 May 16;144(10):705-14.

World Health Organization. (‎2016)‎. Advocacy brief: Combating hepatitis B and C to reach elimination by 2030, 2016. Available at: http://www.who.int/iris/handle/10665/206453 Accessed 11 February 2020.

Gowri V, Chandraleka C, Vanaja R. The current seroprevalence of hepatitis C virus in a tertiary care centre in Vellore, Tamil Nadu. Ind J Commu Med: Official Publication Ind Assoc Prevent Soc Med. 2012 Apr;37(2):137.

Sood S, Malvankar S. Seroprevalence of Hepatitis B surface antigen, antibodies to the Hepatitis C virus, and human immunodeficiency virus in a hospital-based population in Jaipur, Rajasthan. Indian J Community Med. 2010;35:165-9.

Patel PH, Patel HK, Nerurkar AB. Study of prevalence of Hepatitis C virus (HCV) infection in a patients attending tertiary care hospital Valsad, Gujarat, India. Int J Curr Microbiol App Sci. 2017;6:2783-7.

Patil SR, Ghorpade MV, Patil SS, Shinde RV, Mohite ST. Seroprevalence of Antibodies to the Hepatitis C virus in a Hospital–Based Population: A study from western Maharashtra, India. Inter J Collaborative Res Int Med Public Health. 2014;6:102-08.

Vallab B, Bharadwaj G, Vazhavandal G, Uma A, Rajalakshmi PC. Seroprevalence of Hepatitis C Virus Infection among Patients attending a rural teaching hospital in South India: A Three Year Study. Int J Curr Microbiol App Sci. 2014;3:123-7.

Chowdhury A, Santra A, Chaudhuri S, Dhali GK, Chaudhuri S, Maity SG, et al. Hepatitis C virus infection in the general population: a community‐based study in West Bengal, India. Hepatol. 2003 Apr;37(4):802-9.

Sachdeva S, Mehta B. Population-based hepatitis C survey in a rural block. N Am J Med Sci. 2012;4(11):591-2

Singh M, Kotwal A, Gupta RM, Adhya S, Chatterjee K, Jayaram J. Sero-epidemiological and behavioural survey of HIV, HBV and HCV amongst Indian armed forces trainees. Med J Armed Forces India. 2010;66(1):50-4.

Phukan AC, Sharma SK, Das HK, Mahanta J. HCV activity in an isolated community in north east India. Indian J Pathol Microbiol. 2001;44(4):403-5.

Chandra M, Khaja MN, Farees N, Poduri CD, Hussain MM, Aejaz MH, et al. Prevalence, risk factors and genotype distribution of HCV and HBV infection in the tribal population: a community based study in south India. Tropic Gastroenterol: Offic J Digestive Dis Found. 2003;24(4):193-5.

Schwarz TF, Dobler G, Gilch S, Jdger G. Hepatitis C and arboviral antibodies in the isolated population of Mauritius and Rodrigues. J Med Virol. 1994;44:379-84.

Frommel D, Tekle-Haimanot R, Berhe N, Aussel L, Verdier M, Preux PM, et al. A survey of antibodies to hepatitis C virus in Ethiopia. Am J Trop Med Hyg. 1993;49:435-9.

Khan MS, Khalid M, Ayub N, Javed M. Seroprevalence and risk factors of Hepatitis C virus (HCV) in Mardan, NWFP: A hospital based study. Rawal Med J. 2004;29:57-60.

Puri P, Anand AC, Saraswat VA, Acharya SK, Dhiman RK, Aggarwal R, et al. Consensus statement of HCV task force of the Indian National Association for Study of the Liver (INASL). Part I: Status report of HCV infection in India. J Clini Experiment Hepatol. 2014 Jun 1;4(2):106-16.

Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Hughes BL, Page CM, Kuller JA. Hepatitis C in pregnancy: screening, treatment, and management. Am J Obstet Gynecol. 2017;217(5):B2-B12.

Yabaji PM, Shankarkumar A, Shukla A, Bhatia S. Hepatitis C virus infection in a tertiary care hospital in Mumbai, India: Identification of a mixed and novel genotype. Indian J Med Microbiol. 2018;36(3):352-6.

Mengal MA, Abbas F, Mengal MA, Shafee M, Babar S, Mengal MA, et al. Passive surveillance of anti‑hepatitis C virus antibodies in human subjects of four medical units of Balochistan, Pakistan. Int J Agric Biol. 2012;14:585‑9.

Mahgoub A, El Imad T, Al Moussawi H, Daneshvar D, Haddad FG, Saabiye J, et al. Hepatitis C Infection Patterns at a Tertiary Care Center in New York: A Cross-Sectional Study. Cureus. 2018;10(2):e2225.