DOI: http://dx.doi.org/10.18203/2349-3933.ijam20202112

Clinico-epidemiological and pathological profile of lung cancer: a hospital based observational study in Western part of Rajasthan, India

C. R. Choudhary, Suresh Kumar Yogi, Gopal Purohit, Hemant Borana, Govind Desai, Satish Chandra Sharma

Abstract


Background: Lung cancer is the most common cancer causing deaths in men and women world-wide, responsible for over 1 million deaths annually. Although, advances in surgical techniques and combined therapies lung cancer remains a disease with a poor prognosis. Aim of the study was to evaluate the clinico-epidemiological and pathological profile in diagnosed case of lung cancer patients, presenting in the K N Chest hospital.

Methods: Initial evaluation after obtaining informed consent, demography, history, clinicoradiological findings of patients and relevant investigations was recorded. Histopathological reports reviewed.

Results: Our study included 108 patients with confirmed cases of lung cancer.The mean age of the patients was 57.50 years. The male:  female ratio was 5.8:1. Cough was the most common presenting symptom (77.78%) followed by chest pain (62.33%). Clubbing was most commonly associated with squamous cell carcinoma. Most common radiological presentation was consolidation (42.59%) followed by mass lesion (30.55%). Most common histopathological type of lung cancer found in this study was squamous cell carcinoma 47(43.52%) followed by adenocarcinoma 42 (38.89%). Small cell carcinoma was present in 15 (13.89%) and large cell carcinoma was present in 4 (3.70%) study group. The most common pathological cell type in silica dust exposed patient in this study was squamous cell carcinoma followed by adenocarcinoma with occupational history of > 10 years of silica dust exposure in stone mines.

Conclusions: Squamous cell carcinoma still remains the commonest histological subtype followed by adenocarcinoma.


Keywords


Histopathology type, Lung cancer, Smoking, Silica, Squamous cell carcinoma

Full Text:

PDF

References


Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA: Cancer J Clini. 2013 Jan;63(1):11-30..

Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: Cancer J Clini. 2011 Mar;61(2):69-90.

International Agency for Research on Cancer. GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012.

Ferlay J, Soerjomataram I, Ervik M, Dikshit R. GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. Int J Cancer. 2012;136:E359-86.

Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA: Cancer J Clini. 2005 Mar;55(2):74-108.

Sun S, Schiller JH, Gazdar AF. Lung cancer in never smokers—a different disease. Nature Reviews Cancer. 2007 Oct;7(10):778.

Ferlay J, Shin HR, Bray F, Forman D, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Inter J Cancer. 2010 Dec 15;127(12):2893-917.

Scagliotti GV, Longo M, Novello S. Nonsmall cell lung cancer in never smokers. Current Opini Oncol. 2009 Mar 1;21(2):99-104.

Toh CK, Gao F, Lim WT, Leong SS, et al. Never-smokers with lung cancer: epidemiologic evidence of a distinct disease entity. J Clini Oncol. 2006 May 20;24(15):2245-51.

Kawaguchi T, Takada M, Kubo A. Gender, histology, and time of diagnosis are important factors for prognosis: analysis of 1499 never-smokers with advanced non-small cell lung cancer in Japan. J Thoracic Oncol. 2010 Jul 1;5(7):1011-7.

Yano T, Miura N, Takenaka T, Haro A. Never‐smoking nonsmall cell lung cancer as a separate entity: clinicopathologic features and survival. Cancer. 2008 Sep 1;113(5):1012-8.

Govindan R. Lung cancer in never smokers: a new hot area of research. Lancet Oncol. 2010 Apr 1;11(4):304-5.

Radzikowska E, Głaz P, Roszkowski K. Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases. Ann Oncol. 2002 Jul 1;13(7):1087-93.

Samet JM, Avila-Tang E, Boffetta P. Lung cancer in never smokers: clinical epidemiology and environmental risk factors. Clinical Cancer Research. 2009 Sep 15;15(18):5626-45.

Behera D, Balamugsh T. Lung cancer in India. Indian J Chest Dis Allied Sci 2004;46:269-81.

Bhattacharya S, Shukla RK, Kumari R, Kant S. Hanging Trend of Lung Cancer Incidence in Northern India. J Oncol Biom Res. 2014;1(1):22000102.

Mohan A, Latifi A, Guleria R. Increasing incidence of adenocarcinoma lung in India: Following the global trend? Indian J Cancer. 2016 Jan 1;53(1):92.

Dey A, Biswas D, Saha SK. Comparison study of clinicoradiological profile of primary lung cancer cases: An Eastern India experience. Indian J Cancer. 2012 Jan 1;49(1):89.

Gupta RC, Purohit SD, Sharma MP, Bhardwaj S. Primary bronchogenic carcinoma: clinical profile of 279 cases from mid-west Rajasthan. Indian J Chest Dis Allied Sci. 1998;40(2):109-16.

Alberg AJ, Brock MV, Samet JM. Epidemiology Of Lung Cancer". Murray & Nadel's Textbook Of Respiratory Medicine. 6th Ed. Saunders Elsevier; 2016:52.

Vida S, Pintos J, Parent MÉ, Lavoué J, Siemiatycki J. Occupational exposure to silica and lung cancer: pooled analysis of two case-control studies in Montreal, Canada. Cancer Epidemiol Prevention Biomarkers. 2010 Jun 1;19(6):1602-11.

Mandal SK, Singh TT, Sharma TD, Amrithalingam V. Clinico-pathology of lung cancer in a regional cancer center in Northeastern India. Asian Pacific J Cancer Prevention. 2013;14(12):7277.