D-dimer, a biomarker for detecting severity of SARS-CoV2: a systematic review

Shreyans D. Singhvi, Preksha T. Singh, Gautam Bhandari, Rafe M. Khan


A global pandemic of the novel corona virus has impacted the world on severe terms. Not only it has raised an impact on the health care systems as well as the economic and mental health of individuals. SARS-CoV-2 (severe acute respiratory virus- corona virus 2), the outbreak is associated to have likely started as a zoonotic transmission with a seafood market, it has now become clear of the person to person transmission of it. Currently, the virus has been called a global pandemic and has infected 8.72 million people worldwide (dated 21st June 2020). Since, the pandemic has affected multiple countries, our aim of the study is to study d-dimer a biomarker, that may reflect severity of the cases affected by the virus. The search was done based on preferred reporting system for meta-analysis and systemic review (PRISMA) guideline. All the scientific database like Pubmed central, NIH, NCBI, embrase, mediline, Cochrane and google scholar were used to research articles with keywords: ‘d-dimer, ‘SARS-CoV2’, ’severe cases’. All the published peer reviewed articles till date 17th June 2020 were studied. 9 articles were selected in the review and they depicted a higher value of d-dimer can be related to severity of the case of SARS-CoV2. Our study concludes that, for early severe case detection, an early detection of d-dimer levels can be done and treatment to reduce the value in the early cases may provide intervention to the prognosis of the disease. As, the number of cases leading to a severe case and requiring an ICU facility will decline, the mortality rate might drastically decline as well as earlier screening of a severe case of SARS-CoV-2 would help in faster intervention for the same.


D-dimer, SARS-CoV2, Biomarker

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