A cross-sectional study of impact of dyslipidemia in stroke

Authors

  • Niranjan Ganesh Kanagarajan Department of Medicine, Regional institute of medical sciences, RIMS, Imphal, Manipur
  • Reema Ningthoukhongjam Department of Medicine, Regional institute of medical sciences, RIMS, Imphal, Manipur
  • Robinson Ningshen Department of Medicine, Regional institute of medical sciences, RIMS, Imphal, Manipur
  • Thangjam G. Singh Department of Radiodiagnosis, Shija Hospital, Imphal, India
  • Vikie Khruomo Department of Medicine, Regional institute of medical sciences, RIMS, Imphal, Manipur

DOI:

https://doi.org/10.18203/2349-3933.ijam20204518

Keywords:

Cerebro vascular accidents, Hemorrhage, Infarction, Lipid profile, Stroke

Abstract

Background: Stroke is defined as abrupt onset of symptoms and/or sign of focal and global loss of cerebral function lasting for at least 24 hrs with no apparent cause other than of vascular origin. Dyslipidemia in stroke is not widely studied especially from the population of Northeast India (Manipur). Moreover, most prior studies did not specifically compare hemorrhagic stroke risk among those with elevated lipid levels to those with optimal or near optimal lipid levels. Therefore, we studied the levels of different Lipids in stroke patients (hemorrhagic and ischemic) to understand its role in pathogenesis of stroke.  

Methods: This cross-sectional study was conducted in RIMS, Manipur from 2017-2019 and included 185 patients above 18 years with stroke within 48 hrs of onset of symptoms. NCCT brain and serum lipids, other related blood investigations were performed.

Results: We found that serum total cholesterol, LDL-C and triglycerides are significantly higher in infarction patients with average levels of 210.82 mg/dl, 143.64 mg/dl and 151.50 mg/dl respectively which is statistically significant (p<0.001). The average serum total cholesterol, LDL-C and triglycerides are significantly lower in ICH patients with average levels of 143.34 mg/dl, 84.67 mg/dl and 113.94 mg/dl respectively which is statistically significant. (p<0.001).

Conclusions: We concluded that raised level of serum total cholesterol, serum LDL-C, serum triglyceride are associated with cerebral infraction (p=0.001) and lower level of serum total cholesterol, serum LDL-C, serum triglyceride are associated with cerebral hemorrhage (p=0.001). Thus, serum lipid levels should be carefully monitored to prevent life threatening stroke.

Author Biographies

Niranjan Ganesh Kanagarajan, Department of Medicine, Regional institute of medical sciences, RIMS, Imphal, Manipur

Senior Resident, Department of Medicine, RIMS, Imphal

Reema Ningthoukhongjam, Department of Medicine, Regional institute of medical sciences, RIMS, Imphal, Manipur

Senior Resident, Department of Medicine, RIMS, Imphal

Robinson Ningshen, Department of Medicine, Regional institute of medical sciences, RIMS, Imphal, Manipur

Professor, Department of Medicine, RIMS, Imphal

Thangjam G. Singh, Department of Radiodiagnosis, Shija Hospital, Imphal, India

Consultant, Department of Radiodiagnosis, Shija Hospital,                 Imphal

 

Vikie Khruomo, Department of Medicine, Regional institute of medical sciences, RIMS, Imphal, Manipur

Junior resident, Department of Medicine, RIMS, Imphal

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Published

2020-10-21

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Original Research Articles