Prevalence of extra pulmonary tuberculosis among patients registered under a district TB centre in North East India

Krossnunpuii ., Febiola Kharkongor


Background: Worldwide, tuberculosis (TB) is one of the top 10 causes of death and the leading cause from a single infectious agent (above human immunodeficiency virus (HIV)/ acquired immunodeficiency syndrome (AIDS)). Extra pulmonary tuberculosis (EPTB) is TB outside of the lungs. In general, EPTB is more difficult to diagnose than pulmonary TB (PTB), invasive methods are often needed to obtain samples for microbiological and histological testing and in some locations treatment should be extended to avoid the appearance of relapses. The purpose of this study was to find out the prevalence of EPTB among all registered TB patients in a capital city in northeast India.

Methods: A retrospective study conducted at district TB Centre (Aizawl) from data collected from patient’s treatment cards. The study period was 1 year from January 2019 to December 2019. All the registered TB patients except those registered under the programmatic management of drug-resistant TB (PMDT) were included in the study and patients registered under PMDT were excluded. All the analysis was performed using simple percentage method.

Results: Out of 1502 patients, 48.8% were PTB and 51.2% were EPTB. Male comprised of 54.3% and 45.7% were Female. Majority of them (87.5%) were new patients and 10.91% were recurrent cases. History of contacts was given by 8.25% of the patients. Of the 769 EPTB cases, pleural effusion was the most common finding (350) followed by lymph nodes TB (196). Among PTB, majority of them (72.71%) were microbiologically confirmed whereas majority of the patients (84.66%) were clinically diagnosed in EPTB patients.

Conclusions: This study found a high prevalence of HIV-TB co-infections, recurrent TB infection and extra pulmonary tuberculosis.


Tuberculosis, Pulmonary, Extra pulmonary, Recurrent, HIV, Diabetes

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Tuberculosis. World Health Organization. 2020. Available at: tuberculosis. Accessed on 9 September, 2020.

India TB Report 2020. Central TB division. https;// Accessed on 9 September, 2020

Ramirez-Lapausa M, Menendez-Saldana A, Noguerado-Asensio A. Extrapulmonary tuberculosis: an overview. Rev Esp Sanod Penit. 2005;17:3-11.

Sama JN, Chida N, Polan RM, Nuzzo J, Page K, Shah M. High proportion of estrapulmonary tuberculosis in a low prevalence setting: a retrospective cohort study. Public Health. 2016;138:101-7.

Arora VK, Gupta R. Trends of extra-pulmonary tuberculosis under revised national tuberculosis control program: a study from south Delhi. Indian J Tuberc. 2006;53:77-83.

Chander V, Raina SK, Bhardwaj AK, Kashyap S, Gupta AK, Sood A. Clinico-epidemiological profile of extra pulmonary tuberculosis: A report from a high prevalence state of northern India. Public Health Research. 2012;2(6):185-9.

Manjareeka M, Nanda S. Prevalence of HIV infection among tuberculosis patients in eastern India. J Infect Public Heal. 2013;6:358-62.

Lee JY. Dianosis and treatment of extrapulmonary tuberculosis. Tuberc Respir Dis. 2015;78:47-55.

Definitions and reporting framework of tuberculosis -2013 revision. World Health Organization. Available at: definitions/en/. Accessed on 14th September, 2020.

Cox H, Kebede Y, Allamuratova S, Ismailov G, Davletmuratova Z, Byrnes G et al. Tuberculosis recurrence and mortality after successful treatment: impact of drug resistance. PLoS Med. 2006;3(10):e384.

Gadoev J, Asadov D, Harries AD, Parpieva N, Tayler-Smith K, Isaakidis P et al. Recurrent tuberculosis and associated factors: a five year countrywide study in Uzbekistan. PLoS one. 2017;12(5):e0176473.

Hamid Salim MA, Declercq E, Van Deun A, Saki KAR. Gender differences in tuberculosis: a prevalence survey done in Bangladesh. Int J Tuberc Lung Dis. 2004;8(8):952-7.

Pande T, Huddart S, Xavier W, Kulavalli S, Chen T, Pai M et al. Prevalence of diabetes mellitus amongst hospitalized tuberculosis patients at an Indian tertiary care center: a descriptive analysis. PLoS One. 2018;13(7):e0200838.

Collaborative framework for care and control of tuberculosis and diabetes. 2011. World Health Organization. Available at: tb/publications/tb-diabetes-framework/en/. Accessed on 9 September, 2020.

HIV/AIDS. Tuberculosis and HIV. 2020. Available at: World Health Organization. Accessed on 9 September, 2020.

Purohit M, Mustafa T. Laboratory diagnosis of extra-pulmonary tuberculosis (EPTB) in resource-constrained setting: state of the art, challenges and the need. J Clin Diagn Res. 2015;9(4):1-6.