The prognostic accuracy of systemic inflammatory response syndrome, quick sequential organ failure assessment and sequential organ failure assessment scores in estimating the 28 day in-hospital mortality

Malli Dorasanamma, Nikhil Nagireddi, Keerthana Bathyala


Background: Sepsis is among the leading causes of death in the world. 31.5 million cases of sepsis and 19.4 million cases of septic shock have been the annual global incidence. The collaborative efforts have improved the outcomes, yet the in-hospital mortality rates remain high. This study is undertaken to ascertain the prognostic accuracy of systemic inflammatory response syndrome (SIRS), quick sequential organ failure assessment (qSOFA) and sequential organ failure assessment (SOFA) scores in estimating the in-hospital mortality.

Methods:  A prospective observational study was done from the department of general medicine and intensive care units from December 2017 to September 2019. A total of 50 Sepsis patients were selected for the study. The patients have been monitored for 28 days. Data regarding demographics, illness severity, organ dysfunction, length of stay and outcome (for 28 days) of the patients are noted.

Results: The SOFA score with AUROC of 0.82, had the best discrimination in predicting mortality.

Conclusions: SOFA has better prognostic accuracy than SIRS and qSOFA in predicting mortality. As ICU mortality is high in this group and care should be resource-intensive due to increased length of stay.


Sepsis, SOFA, qSOFA, SIRS, India

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