DOI: http://dx.doi.org/10.18203/2349-3933.ijam20204973

Profile of microalbuminuria in non-diabetic myocardial infarction

Ramesh Thanikachalam, Jercy Grace, Appandraj Srivijayan

Abstract


Background: Urinary albumin excretion between 20 to 200 mg per litre is defined as microalbuminuria (MAU). MAU acts as a marker for endothelial cell destruction and is associated with atherosclerosis in both diabetics and non-diabetics. This study aimed to assess the MAU prevalence in nondiabetic patients with myocardial infarction.

Methods: A cross-sectional study was conducted at tertiary care hospital. Among non-diabetic patients with myocardial infarction. The study was conducted from October 2019 to March 2020. All patients were subjected to complete physical examination, electrocardiography (ECG) and echocardiography. Quantitative determination of MAU was done in a urine sample. Diagnostic coronary angiogram was performed for all patients. Appropriated statistical tests were applied.

Results: Among 80 study participants, 73.75% were men, and 26.25% were women. Smoking habit was present among 60%, and 56.25% were hypertensive. The prevalence of microalbuminuria was 27.5%. A statistically significant difference was seen between TIMI scoring and presence of MAU (p<0.001). The difference in vessels type between the microalbuminuria status was found to be significant (p=0.005).

Conclusions: Evidence from this study shows that the presence of MAU had a strong association between myocardial infarction and its application as a risk factor of cardiovascular diseases in general non-diabetic population proves practical.


Keywords


Microalbuminuria, Non-diabetic, Myocardial infarction

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References


Noyes AM, Eckardt K. Microalbuminuria as a risk factor for cardiovascular disease in healthy individuals: a case report and review of the literature. Conn Med. 2013;77(7):399-402.

Hao G, Wang ZW, Zhang L, Chen Z, Wang X, Guo M, et al. Prevalence of microalbuminuria among middle-aged population of China: A multiple center cardiovascular epidemiological study. Angiology. 2014;66(1):49-56.

Hillege HL, Janssen WMT, Bak AAA, Diercks GFH, Grobbee DE, Crijns HJGM, et al. Microalbuminuria is common, also in a nondiabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. J Intern Med. 2001;249(6):519-26.

Wang Y, Yuan A. Correlation between microalbuminuria and cardiovascular events. Int J Clin Exp Med. 2013;6(10):973-8.

Damsgaard E, Frøland A, international OJ-K. Eight to nine year mortality in known non-insulin dependent diabetics and controls. Kidney. Int.1992;41(4):731-5.

Mattock M, Morrish N, Viberti G, Keen H, Fitzgerald, Jackson G. Prospective study of microalbuminuria as predictor of mortality in NIDDM. Diabetes. 1992;41(6):736-41.

Jarrett RJ, Viberti GC, Argyropoulos A, Hill RD, Mahmud U, Murrells TJ. Microalbuminuria Predicts Mortality in Noninsulin‐dependent Diabetes. Diabet Med. 1984;1(1):17-9.

Mogensen CE. Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med. 1984;310(6):356-60.

Viberti G, Jarrett R, Mahmud, Hill RD, Argyropoulos A, Mahumud U, Keen H. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancent. 1982;1(8287):1430-2.

Cerasola G, Cottone S, Mule G, Nardi E, Mangano M, Andronic G et al. Microalbuminuria, renal dysfunction and cardiovascular complication in essential hypertension. J Hypertens. 1996;14(7):915-20.

Agrawal B, Berger A, Wolf K, Luft F. Microalbuminuria screening by reagent strip predicts cardiovascular risk in hypertension. J Hypertens. 1996;14(2)223-8.

Agewall S, Wikstrand J, Ljungman S, Herlitz H, Fagerberg B. Does microalbuminuria predict cardiovascular events in nondiabetic men with treated hypertension?. Am J Hypertens. 1995;8(4):337-42.

Parving H, Mogensen C, Jensen A, Evrin P. Increased urinary albumin-excretion rate in benign essential hypertension. Lencent. 1974;1(7868):1190-2.

Yudkin J, Forrest R, Jackson C. Microalbuminuria as predictor of vascular disease in non-diabetic subjects: Islington Diabetes Survey. Lencent. 1988;2(8610):530-3.

Pedrinelli R, Penno G, Dell’Omo G, Bandinelli S, Giorgi D, Di Bello VD, et al. Microalbuminuria and transcapillary albumin leakage in essential hypertension. Hypertension. 1999;34(3):491-5.

1Bakris GL, Randall O, Rahman M. Associations between cardiovascular risk factors and glomerular filtration rate at baseline in The African American Study of Kidney Disease (AASK) Trial. J Am Soc Nephrol.1998;9:139.

Al-Saffar HB, Nassir H, Mitchell A, Philipp S. Microalbuminuria in non-diabetic patients with unstable angina/non ST-segment elevation myocardial infarction. BMC Res Notes. 2015;8:371.

Sharma S, Ghalaut VS, Dixit R, Kumar S, George PJ. Microalbuminuria and C-reactive protein as a predictor of coronary artery disease in patients of acute chest pain. J cardiovasc dis res. 2013;4(1):37-9.

Currie G, Dells C. Proteinuria and its relation to cardiovascular disease. Int J Nephrol Renovasc Dis. 2013;7:13-24.

Won JC, Lee YJ, Kim JM, Han SY, Noh JH, Ko KS, et al. Prevalence of and factors associated with albuminuria in the Korean adult population: The 2011 Korea National Health and Nutrition Examination Survey. PLoS One. 2013;8(12):e83273.

Klausen K, Borch-Johnsen K, Feldt-Rasmussen B, Jensen G, Clausen P, Scharling H, et al. Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes. Circulation. 2004;110(1):32-5.

Guízar JM, Kornhauser C, Malacara JM, Amador N, Barrera JA, Esparza R. Renal functional reserve in patients with recently diagnosed type 2 diabetes mellitus with and without microalbuminuria. Nephron. 2001;87(3):223-30.

Diercks GF, Hillege HL, van Boven AJ, Kors JA, Crijns HJ, Grobbee DE, et al. Microalbuminuria modifies the mortality risk associated with electrocardiographic ST-T segment changes. J Am Coll Cardiol. 2002;40(8):1401-7.

Pedrinelli R, Dell'omo G, Catapano G, Giampietro O, Carmassi F, Matteucci E, et al. Microalbuminuria and endothelial dysfunction in essential hypertension. Lancet. 1994;344(8914):14-8.

Hollenberg NK. Urinary albumin excretion predicts cardiovascular and non-cardiovascular mortality in general population. Curr hypertens rep. 2003;5(5):356-7.