Pharmacognostical and pharmaceutical analysis of Triphala Kajjali tablet-an ayurvedic herbomineral formulation for metabolic syndrome

Authors

  • Jaynika S. Garasia Department of Kayachikitsa, Gujrat Ayurved University, IPGT and RA Jamnagar, Gujarat, India
  • Mandip Goyal Department of Kayachikitsa, Gujrat Ayurved University, IPGT and RA Jamnagar, Gujarat, India
  • Harisha C. R. Department of Pharmacognosy, IPGT and RA Jamnagar, Gujarat, India
  • Vinay J. Shukla Pharmaceutics Laboratory, IPGT and RA Jamnagar, Gujarat, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20210263

Keywords:

Triphala kajjali, Metabolic syndrome, Pharmacognosy, Pharmaceutical analysis

Abstract

Background: Triphala is one of the most easily available and commonly used medicine which contains fine powder of three fruits viz. Terminalia chebula Retz. (Haritaki), Terminalia bellerica Roxb. (Bibhitaki) and Embilica officinalis Gaertn. (Amalaki) and is indicated as one of the drugs for management of disorders of Kapha and Meda. Due to bitter and astringent taste of Triphala in the powder form is a major complaint of the patients. So, to discover that form of Triphala, which is easy to take, effective in low dose, has long shelf life and simple to dispense is the need. For assurance of quality of herbal compounds pharmacognostical and pharmaceutical analysis should be done. 

Methods: Triphala Kajjali was subjected to microscopic evaluation for pharmacognostical, physiochemical analysis like hardness, weight variation, loss on drying, ash value, acid insoluble extract, pH value, water soluble extract, alcohol soluble extract and high-performance thin layer chromatography (HPTLC).

Results: Pharmacognostical study showed the presence of certain identifying characters of all of the ingredients of Triphala Kajjali that is Haritaki, Bibhitaki and Amalaki. In pharmaceutical study, preliminary physiochemical analysis showed that hardness of the tablet was 2.05 kg/cm2, ash value 4.03%w/w, loss on drying 5.5%w/w, water soluble extract 5.89%w/w, alcohol soluble extract 25.96%w/w and HPTLC showed 7 spots in 254 nm and 7 spots in 366 nm.

Conclusions: Pharmacognostical and physico-chemical observations revealed the specific characters of all active constituents of Triphala Kajjali and confirmed the purity and genuinity of the drug.

Author Biography

Jaynika S. Garasia, Department of Kayachikitsa, Gujrat Ayurved University, IPGT and RA Jamnagar, Gujarat, India

Institute for post graduate teaching and research in ayurveda Jamnagar. Department of Kaya chikitsa

References

Sharma S, Tarangini R, ed Shashtri K. Banarasidas ML. Varanasi reprint, 11th ed, 2009;6:112-26.

Shah DP, Zala V, Damre A, Sathaye SS. Evaluation of bioavailability enhancement by Kajjali, an ayurvedic proprietary herbomineral product, Conference Paper in Drug Metabolism Reviews, 16th North American Regional International society for the study of xenobiotics Meeting, October 2009. Available from: www.issx. confex.com/issx/16na/webprogram/paper17724.html. Accessed on 16 July 2015.

The Ayurvedic Formulary of India, Department of Indian Systems of Medicine and Homeopathy, Ministry of Health and Family Welfare, Govt. of India, New Delhi, 2003, 2nd ed, Part I. Available at:

https://dravyagunatvpm.files.wordpress.com/2009/02/afi-part-i_part_a_formulations1.pdf

The Ayurvedic Formulary of India, Department of Indian Systems of Medicine and Homeopathy, Ministry of Health and Family Welfare, Govt. of India, New Delhi, 2000, 1st ed, Part II. Available at: https://dravyagunatvpm.files.wordpress.com/2009/02/afi_part_ii_formulations.pdf

Sadananda S, Tarangini R. In: Shastri K, editor. 6/124. New Delhi: Motilal Banarasidas; 1970;127.

Sukshma Aushadhi Kalpana Written and published by Pra. Vaidya Narahar Bhole Prabhu pratham aawritti. 2014;14.

Trease, Evans. Pharmacognosy, 15th Ed, WB Sunders Company Ltd. 1996;569-70.

Wallis TE. Text book of Pharmacognosy, 5th Ed, New Delhi: CBS Publishers and Distributors. 2002;123-32:210-5.

Ayurvedic pharmacopeia of India part 1 vol I. Available at: http://www.ayurveda.hu/api/API-Vol-1.

CCRAS. General guidelines for drug development of ayurvedic formulations. 2009.

Planner Chromatography, Modern Thin layer Chromatography, Switzerland. 1999;2-16.

Ayurvedic pharmacopeia of India part 1 vol I. pdf Available at https://dravyagunatvpm.files.wordpress.com/2009/02/api-vol-1-monographs1.pdf. Accessed on Accessed on 16 July 2015.

Downloads

Published

2021-01-27

Issue

Section

Original Research Articles