DOI: http://dx.doi.org/10.18203/2349-3933.ijam20211048

Blood pressure profile in freshly diagnosed alcohol dependence syndrome patients

M. M. Pasha, Harpreet Singh Dhillon, Bhupendra Yadav, Anil Dalal, Shibu Sasidharan

Abstract


Background: Alcohol consumption and raised Blood pressure (BP) are among the top five risk factors responsible for the growing global non-communicable diseases (NCD) burden. The present study was undertaken to study the relationship between alcohol dependence syndrome (ADS) and hypertension and the effect of reduction in alcohol consumption on BP.

Methods: A prospective observational study was conducted at a tertiary care hospital over a period of 02 years from 08 Oct 2016 to 02 Oct 2018. A total of fifty freshly diagnosed ADS patients with BP in the hypertensive range after the withdrawal subsided, were recruited into the study. The study group was subjected to repeated BP measurements, serum Gamma glutamyl transferase (GGT) measurements and status of alcohol consumption at 03, 06, 09 and 12 monthly intervals. The data was analyzed with ANOVA, Post-hoc Bonferroni and Pearson’s correlation tests.

Results: There was a statistically significant mean decrease in systolic and diastolic blood pressure from the baseline till 03 months and between 03 months and 06 months of follow-up. The correlation between GGT levels and systolic and diastolic BP at different time intervals showed that there was a statistically non-significant weak positive correlation at baseline (r value=0.125) (p value= 0.38). During follow-up period there was a negative correlation between GGT and systolic BP at 12 months (r value= -0.40), which was statistically significant. The correlation between alcohol consumption and BP at different time intervals showed a moderate positive correlation at baseline with systolic BP(r value= 0.478), which was statistically significant.

Conclusions: This study evaluated changes in blood pressure occurring during Alcohol dependence syndrome treatment. Observed decreases in systolic and diastolic blood pressure were substantially accounted for by reductions in alcohol consumption and occurred largely in the first 03 months of treatment. There was no significant fall in systolic blood pressure between 06 months and 01-year duration of follow-up.


Keywords


Alcohol dependence syndrome, Blood pressure, GGT

Full Text:

PDF

References


Mannelli P, Pal CU. Medical comorbidity and alcohol dependence. Curr Psychiatry. 2007;9:217-24.

Cushman WC. Alcohol Consumption and Hypertension. The Journal of Clinical Hypertension. 2007;3:3.

Kazim H, Rais AA, Leon F. Alcohol-induced hypertension: Mechanism and prevention. World J Cardiol. 2014;6(5):245-52.

Charlet K, Heinz A. Harm reduction-a systematic review on effects of alcohol reduction on physical and mental symptoms. Addiction Biology. 2016;22:1119-59.

Pajak A, Szafranic K, Kubrinova R, Milyutina S, Peasey A, Pikhart H, et al. Binge Drinking and blood pressure: Cross-sectional results of the HAPIEE Study. PLoS ONE. 2013;8(6):e65856.

Puddey IB, Zilkens RR, Beilin LJ. Alcohol, blood pressure and hypertension. Comprehensive Handbook of Alcohol Related Pathology. Oxford, UK: Elsevier Academic. 2005;607-26.

Wakabayashi I. Influence of Gender on Associationof Alcohol Drinking with Blood Pressure. Am J Hypertens. 2008;21:1310-1317.

Rapromaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, et al.Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life years lost, and age specific associations in 1.25 million people. The Lancet. 2014;383:1899-911.

Mancia G. 2013 ESH/ESC guidelines for the management of arterial hypertension: The Task Force for management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013;31:1281-357.

Whelton PK. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APHA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task force on Clinical Practice Guidelines.Hypertension. 2017;13:pii.

Paulman PM, Paulman AA, Jarzynka LJ, Falk NP. Taylor’s Manual of Family Medicine.2015;4:275-282.

Roerecke M, Kaczorowshi J, Tobe SW, Gmel G. The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis. The Lancet Public Health.2017;2:e108-e120.

Volkow ND. Principles of drug addiction treatment: A research-based guide. DIANE Publishing. 2011.

Frank D, DeBenedetti AF, Volk RJ,Williams EC. Effectiveness of the AUDIT-C AS A SCREENING TEST FOR Alcohol Misuse in three rece/Ethnic Groups. J Gen Intern Med. 2008;23(6):781-787.

Xin X, He J, Frontini MG, Ogden LG, Motsamai OI, Whelton PK. Effects of alcohol reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2001;38(5):1112-7.

Baros AM, Wright TM, Latham PK, Miller PM, Anton RF. Alcohol consumption, % CDT, GGT and blood pressure change during alcohol treatment. Alcohol Alcoholism. 2008;43(2):192-7.2):1-5.