Hypolipidemia: a study evaluating magnitude and underlying etiologies of the entity

Navgeet Mathur, Amit Mehta, Medha Mathur


Background: Hyperlipidemia is a common and well-known entity as it is one of the risk factors of various noncommunicable diseases. Hypolipidemia is an entity which is very less known among health care givers. Currently available data about this entity is insufficient and nonconclusive.

Methods: This study was a prospective observational study. Lipid profile reports at the central lab of the institute was observed and among them hypolipidemia reports and related patients were identified. Patients were further evaluated and classified into 10 etiological categories.

Results: Total 450 lipid profile reports were observed out of which 36 (8%) reports had hypolipidemia. Most patients had hypolipidemia were having chronic illness (41.7%) or critical illness (33.3%) followed by malnutrition (11.1%), idiopathic etiology (11.1%), moderate to severe anemia (8.3%), chronic liver disease (8.3%), cancer (5.5%), statin use for more than 3 months (2.8%), malabsorption (2.8%), hyperthyroidism (0%).

Conclusions: Awareness about hypolipidemia among health care givers is needed to look out for underline diseases with consequences and to have active participation to unsolved the mystery of this entity. Overuse of antihyperlipidemic drugs should be avoided. This study highlighted causes and consequences of hypolipidemia.


Anemia, Antihyperlipidemic drugs, Hypolipidemia

Full Text:



Mathur N, Mathur M. A study of risk factors related to coronary vascular disease among patients attending a tertiary health care institute of Rajasthan. Int J Sci Res. 2017;6:112-3.

Mathur M, Mathur N. Stroke: Risk factors evaluation in patients attending a tertiary health care institute of Rajasthan. Paripex. Indian J res. 2017;6:1-3.

Mathur M, Mathur N, Singh O, Solanki J, Soni P, Sarwa A et al. Demographic characters and factors favouring emergence of diabetes mellitus type two. Int J Res Med Sci. 2018;6:950-4.

Elmehdawi RR. Hypolipidemia: a word of caution. Libyan J Med. 2008;3:84-90.

Glueck CJ, Kelley W, Gupta A, Fontaine RN, Wang P, Gartside PS. Prospective 10-year evaluation of hypobetalipoproteinemia in a cohort of 772 firefighters and cross-sectional evaluation of hypocholesterolemia in 1,479 men in the National Health and Nutrition Examination Survey I. Metabolism. 1997;46(6):625-33.

Yokoyama M, Suto Y, Sato H, Arai K, Waga S, Kitazawa J et al. Low serum lipids suggest severe bone marrowfailure in children with aplastic anemia. Pediatr Int. 2000;42:613-9.

Swanson CA, Potischman N, Barrett RJ, Berman ML, Mortel R, Twiggs LB et al. Endometrial cancer risk in relation to serum lipids and lipoproteinlevels. Cancer Epidemiol Biomarkers Prev. 1994;3:575-81.

Nomura AM, Stemmermann GN, Chyou PH. Prospectivestudy of serum cholesterol levels and large-bowel cancer. J Natl Cancer Inst. 1991;83:1403-7.