DOI: https://dx.doi.org/10.18203/2349-3933.ijam20214856
Published: 2021-12-23

Wild mushroom poisoning in Kumaon region of Uttarakhand: a case series

Vinita Nikhurpa, Mamta Nikhurpa

Abstract


Mushrooms have been dietary source in hilly and ethnic tribes of India. More than 5000 mushroom species are known worldwide and nearly 100 species are known to be poisonous for humans. Mushroom poisoning occurs due to unintentional and accidental ingestion of poisonous mushroom due to misidentification of poisonous variety as edible one. There has been increasingly incidence of reporting of mushroom poisoning cases nowadays. Here we are reporting case series of 4 patients admitted hailing from same village with accidental ingestion of poisonous mushrooms with clinical-laboratory profile and outcome at our institution. Mushroom Poisoning is an emerging healthcare concern nowadays. Education and mass awareness for identification of poisonous mushrooms is an important preventive measure. Early hospitalization, proper hydration, gastric decontamination, silibinin and N- acetyl cysteine therapy with hepato-renal support constitutes mainstay of treatment. Delay in treatment and complications results in poor prognosis and mortality.


Keywords


Wild mushroom, Amanita poisoning, Poisoning

Full Text:

PDF

References


Jha SK, Tripathi NN. Recent scenario in diversity, distribution and applied value of macro-fungi: a review. Int J Univ Pharm Life Sci. 2012;2:102-25.

Marmion VJ, Wiedemann TE. The death of Claudius. J R Soc Med. 2002;95(5):260-1.

Karlson-Stiber C, Persson H. Cytotoxic fungi-an overview. Toxicon. 2003;42:339-49.

Enjalbert F, Rapior S, Nouguier-Soul_e J, Guillon S, Amouroux N, Cabot C. Treatment of amatoxin poisoning: 20-year retrospective analysis. J Toxicol Clin Toxicol. 2002;40:715-57.

Kantola T, Kantola T, Koivusalo AM, Höckerstedt K, Isoniemi H. Early molecular adsorbents recirculating system treatment of Amanita mushroom poisoning. Ther Apher Dial. 2009;13:399-403.

Verma N, Bhalla A, Kumar S, Dhiman RK, Chawla YK. Wild mushroom poisoning in North India: case series with review of literature. J Clin Exp Hepatol. 2014;4:361-5.

Koppel C. Clinical symptomatology and management of mushroom poisoning. Toxicon. 1993;31:1513-40.

Derenzini M, Betts CM, Busi C, et al. Ultrastructural changes in beta-cells of pancreatic islets in alpha-amanitin-poisoned mice. Virchows Arch B Cell Pathol. 1978;28:13-20.

Garg MS. Mushroom poisoning. MJAFI. 2003;59:266-8.

Zellner T, Prasa D, Färber E, Hoffmann-Walbeck P, Genser D, Eyer F. The use of activated charcoal to treat intoxications. Dtsch Arztebl Int. 2019;116:311-7.

Assessment of α-amanitin toxicity and effects of silibinin and penicillin in different in vitro models. Popp T, Balszuweit F, Schmidt A, Eyer F, Thiermann H, Steinritz D Toxicol In Vitro. 2020;67(1):104921.

Faulstich H, Jahn W, Wieland T. Silybin inhibition of amatoxin uptake in the perfused rat liver. Arzneimittelforschung. 1980;30:452-4.

Liu J, Chen Y, Gao Y. N-acetylcysteine as a treatment for amatoxin poisoning: a systematic review. Clin Toxicol (Phila). 2020:1-8.

Escudié L, Francoz C, Vinel JP. Amanita phalloides poisoning: reassessment of prognostic factors and indications for emergency liver transplantation. J Hepatol. 2007;46:466-73.

Ganzert M, Felgenhauer N, Zilker T. Indication of liver transplantation following amatoxin intoxication. J Hepatol. 2005;42:202-9.

Wittebole X, Hantson P. Use of the molecular adsorbent recirculating system (MARS) for the management of acute poisoning with or without liver failure. Clin Toxicol (Phila) 2011;49:782-93.

Barman B, Lynrah KG, Tiewsoh I. Mushroom Poisoning. 2018;114.