A study on association of serum magnesium, serum uric acid levels and microalbuminuria in patients with type 2 diabetes mellitus

Shubham Jain, Birata Debbarma, Devdas Rai


Background: Microalbuminuria is multifactorial and it is an important marker for diabetic nephropathy. The aim of the study was to assess the incidence and association of serum magnesium levels, serum uric acid levels and microalbuminuria in patients with type 2 DM.

Methods: This study was a cross-sectional study conducted for a period of 2 years from October 2015 to September 2017, where the patients diagnosed as type 2 DM admitted in AJIMS were taken up for the study. All the patients’ blood sample was sent for estimation of serum magnesium, serum uric acid, FBS, PPBS, HBA1C and urine spot albumin:creatinine ratio.

Results:In our study, out of 100 patients with type 2 diabetes, 79 patients had microalbuminuria. Out of these, 83.3% (N=75) was having hypomagnesemia (p<0.000) associated with microalbuminuria. Hyperuricemia was seen in 63% (N=63) of the population but 79.4% (N=50) hyperuricemics were associated with microalbuminuria(p<0.000).

Conclusions:There was a significant microalbuminuria in patients with type 2 DM, with reduced serum Mg levels and elevated serum uric acid levels as compared with patients who had serum Mg and uric acid levels within the normal range. 



Magnesium, Uric acid, Microalbuminuria, Type 2 diabetes

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Akhtar SN, Dhillon P. Prevalence of diagnosed diabetes and associated risk factors: Evidence from the large-scale surveys in India. J Social Health Diab. 2017;1(5):28.

Odusan OO, Familoni OB, Odewabi AO, Idowu AO, Adekolade AS. Patterns and correlates of serum magnesium levels in subsets of type 2 diabetes mellitus patients in Nigeria. Indian J Endocrinol Metab. 2017;21:439-42.

Volpe SL. Magnesium, the metabolic syndrome, insulinresistance, and type 2 diabetes mellitus. Crit Rev Food Sci Nutr. 2008;48:293-300.

Erasmus RT, Olukoga AO, Alanamu RA, Adewoye HO, Bojuwoye B. Plasma magnesium and retinopathy in black African diabetics. Trop Geogr Med. 1989;41: 234-7.

Emadyan O. Relationship between the clinical scoring and demyelination in central nervous system with total antioxidant capacity of plasma during experimental autoimmune encephalomyelitis development in mice. Neurosci Lett. 2007;412(1):24-8.

Greene DA, Stevens MJ, Obrosova I, Feldman EL. Glucoseinduced oxidative stress and programmed cell death in diabetic neuropathy. Eur J Pharmacol. 1999; 375(3):217-23.

Xueting H , Shuang R , Qiang W , Taoping S , Wei B , Liangkai C , et al. Association between plasma uric acid and insulin resistance in type 2 diabetes: a Mendelian randomization analysis. Diab Res Clin Pract. 2021;171:10854.

American Diabetes Association. Glycemic targets: standards of medical care in diabetes-2018. Diab Care. 2017;41:S55-64.

De Oliveira EP, Burini RC. High plasma uric acid concentration: causes and consequences. Diabetol Metab Syndr. 2012;4:12.

Alhosaini M, Leehey DJ. Magnesium and dialysis: the neglected cation. Am J Kidney Dis. 2015;66:523-31.

Chin-Hsiao T. Correlation of uric acid and urimnary albumin excretion rate in patients with type 2 diabetes mellitus in Taiwan. Kidney Int. 2005;68:796-801.

Xu B, Jichao S, Xinru D, Xiaolin H, Wanwan S, Yu X, et al. Low Serum magnesium level is associated with microalbuminuria in chinese diabetic patients. Int J Endocrinol. 2013;34:123-8.

Gupta AD, Sharma D, Saikia UK. Hypomagnesemia in T2DM. Indian J Endocrinol Metab. 2012;16(6): 1000-3.

Ning S, Kuang HY, Wang N, Gao XY, Hao M, Zou W, et al. Relationship between oxidant/ antioxidant markers and severity of microalbuminuria in the early stage of nephropathy in type 2 diabetic patients. J Diab Res. 2013;12:41-9.

Altura BT, Altura BM. Endothelium-dependent relaxation in coronary arteries requires magnesium ions. Br J Pharmacol. 1987;91(3):449-51.

Bonakdaran S, Shakeri MT. Hyperuricemia amd albuminuria in patients with T2DM. Iran J Kidney Dis. 2011;5(1):21-4.

Bakker SJ, Gans Ro, Ter Maaten JC. The potential role of adenosine in the pathophysiology of the insulin resistance syndrome. Atherosclerosis. 2001; 155:283-90.

Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, et al. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?. Hypertension. 2003;41(6):1183-90.

American Diabetes Association. Diabetic Nephropathy. Diab Care. 2003;26:S94-8.