Unna-Thost type of palmoplantar keratoderma: a case report

Authors

  • K. S. Dhillon Department of Dermatology, Era’s Lucknow Medical College, Lucknow, UP, India
  • Vidhi Agarwal Department of Dermatology, Era’s Lucknow Medical College, Lucknow, UP, India
  • Tarunveer Singh Department of Dermatology, Era’s Lucknow Medical College, Lucknow, UP, India
  • Deepak Sharma Department of Dermatology, Era’s Lucknow Medical College, Lucknow, UP, India
  • Areeba Khan Department of Dermatology, Era’s Lucknow Medical College, Lucknow, UP, India
  • Ritika Srivastava Department of Dermatology, Era’s Lucknow Medical College, Lucknow, UP, India
  • Sweksha Srivastava Department of Dermatology, Era’s Lucknow Medical College, Lucknow, UP, India
  • Soni Yadav Department of Dermatology, Era’s Lucknow Medical College, Lucknow, UP, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20150564

Keywords:

Unna-Thost, Palmoplantar keratoderma

Abstract

Non-epidermolytic variety of hereditary palmoplantar keratoderma with autosomal dominant inheritance characterised by uniform, thick, yellow hyperkeratosis over palms and soles was first described separately by Thost and Unna and named as Unna-Thost Keratoderma. We present a case of Unna-Thost keratoderma in a 9 year old male child who presented with waxy, thick, yellow palms and soles with fissures and contractures in hands.

References

Kimyai-Asadi, A’Kotcher LB, Jih MH. The molecular basis of hereditary palmoplantar keratodermas. J Am Azad Dermatol.2002;47;327-43.

Kuster W, Becker A. Indication for the identity of palmoplantar keratoderma Unna Thost with type Vörner. Acta Derm Venereol (Stockh) 1992;72:120–2.

Kansky A, Durinovic-Belló I, de Jongh BM et al. HLA antigens in Yugoslav patients with palmoplantar keratoderma, type Unna–Thost: a family study. Acta Derm Venereol (Stockh). 1982;62:313–6.

Gamborg-Nielsen P. Two different clinical and genetic forms of hereditary palmoplantar keratoderma in the northernmost county of Sweden. Clin Genet. 1985;28:361–6.

Kanitakis J, Tsoitis G, Kanitakis C. Hereditary epidermolytic palmoplantar keratoderma (Vorner type). Report of a familial case and review of the literature. J Am Acad Dermatol. 1987;17:414-22.

Umegaki N, Nakano O, Tamai K, et al. Vörner type palmoplantar keratoderma: novel KRT9 mutation associated with knuckle pad-like lesions and recurrent mutation causing digital mutilation. Br J Dermatol. 2011;165:199–201.

Vorner H. Zur Kenntniss des Keratoma hereditarium palmare et plantare. Arch Derm Syph. 1901;56:3-31.

Thost A. Ueber Erbliche Ichthyosis Palmaris et Plantaris Cornea. Dissertation. Heidelberg, Germany: University of Heidelberg; 1880.

Kuster W, Becker A. Indication for the identity of palmoplantar keratoderma type Unna-Thost with type Vorner. Thost's family revisited 110 years later. Acta Derm Venereol. 1992;72:120-2.

Kanitakis J, Tsoitis G, Kanitakis C. Hereditary epidermolytic palmoplantar keratoderma (Vorner type). Report of a familial case and review of the literature. J Am Acad Dermatol. 1987;17:414-22.

Irvine AD, Paller AS. Molecular genetics of the inherited disorders of cornification: an update. Curr Probl Dermatol.2002;14:84-6.

Lucker GP, van de Kerkhof PC, Steijlen PM. Topical calcipotriol in the treatment of epidermolytic palmoplantar keratoderma of Vorner. Br J Dermatol. 1994;130:543-5.

Hennies HC, Kuster W, Langbein L, et al. Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK). Am J Hum Genet. 1993;53:A211.

Reis A, Hennies HC, Langbein L, et al. Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK). Nat Genet. 1994;6:174-9.

Downloads

Published

2017-02-09