Mycosis fungoides: cutaneous T-cell lymphoma

Authors

  • Tarunveer Singh Department of Dermatology, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India
  • Kanwarjit S. Dhillon Department of Dermatology, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India
  • Deepak Sharma Department of Dermatology, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India
  • Mohd Sadiq Umar Department of Dermatology, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India
  • Uroos Fatima Department of Pathology, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India
  • K. R. Varshney Department of Microbiology, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India
  • Alankret Dhillon III MBBS-Part B, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India

Keywords:

Mycosis fungoides, Cutaneous T-cell lymphoma, Epidermotropism

Abstract

Mycosis fungoides (MF) is the most common group of cutaneous T-cell lymphomas. It is a rare non-Hodgkin’s lymphoma of mature, skin-homing, clonal, malignant T lymphocytes, usually observed in mid to late adulthood, that initially presents in the skin as patches, plaques, tumors, or generalized erythema (erythroderma) and can involve the lymph nodes and peripheral blood. In this review, we survey the MF literature of the last decade and highlight the major trends.

References

Rapini Ronald P, Bolognia Jean L, Jorizzo Joseph L. Mycosis fungoides. In: 1. Rapini Ronald P, Bolognia Jean L, Jorizzo Joseph L, eds. Dermatology. 2nd ed. St. Louis: Mosby; 2007: 1867.

Alibert JLM. Descriptions des maladies de la peau observées a l’Hôpital Saint-Louis, et exposition des meilleures méthodes suivies pour leur traitement (in French). Paris: Barrois l’ainé. 1806: 286.

Cerroni Lorenzo, Kevin Gatter, Helmut Kerl. An illustrated guide to skin lymphomas. Cerroni Lorenzo, Kevin Gatter, Helmut Kerl, eds. A Guide. Malden, Massachusetts: Blackwell Publishing; 2005: 13.

Kim EJ, Junkins-Hopkins JM, Vittorio CC, Rook AH. Mycosis Fungoides and Sezary syndrome: an update. Curr Oncol Rep. 2006;8:376-86.

Hess Schmid M, Dummer R, Kempf FW, Hilty N, Burg G. Mycosis fungoides with mucinosis follicularis in childhood. Dermatology. 1999;198:284-7.

Elmer KB, George RM. Cutaneous T-cell lymphoma presenting as benign dermatoses. Am Fam Physician. 1999;59:2809-13.

Neuhaus IM, Ramos-Caro FA, Hassanein AM. Hypopigmented mycosis fungoides in childhood and adolescence. Pediatr Dermatol. 2000;17:403-6.

Rodriguez-Vazquez M, Garcia-Arpa M, Gonzalez-Garcia J. Juvenile mycosis fungoides treated with bexarotene and PUVA. Int J Dermatol. 2007;46:99-102.

Tan E, Tay YK, Giam YC. Profile and outcome of childhood mycosis fungoides in Singapore. Pediatr Dermatol. 2000;17:352-6.

Annessi G, Paradisi M, Angelo C, Perez M, Puddu P, Girolomoni G. Annular lichenoid dermatitis of youth. J Am Acad Dermatol. 2003;49:1029-36.

Pabsch H, Rutten A, Van Stemm A, Meigel W, Sander CA, Schaller J. Treatment of childhood mycosis fungoides with topical PUVA. J Am Acad Dermatol. 2002;47:557-61.

Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105(10):3768-85.

Olsen E, Vonderheid E, Pimpinelli N, Willemze R, Kim Y, Knobler R, et al. Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous task force of the European Organization for Research and Treatment of Cancer (EORTC). Blood. 2007;110(6):1713-22.

Olsen EA, Whittaker S, Kim YH, Duvic M, Miles Prince H, Lessin SR, et al. Clinical end points and response criteria in mycosis fungoides and Sezary syndrome: a consensus statement of the international society for cutaneous lymphomas, the United Stated Cutaneous Lymphoma Consortium, and the cutaneous lymphoma task force of the European Organisation for Research and Treatment of Cancer. J Clin Oncol. 2011;29(18):2598-607.

Hortwitz SM, Olsen EA, Duvic M, Porcu P, Kim YH. Review of the treatment of mycosis fungoides and Sezary syndrome: a stage-based approach. J Natl Compr Canc Netw. 2008;6(4):436-42.

Dummer R, Dreyling M. Primary cutaneous lymphoma: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2008;19(Suppl 2):72-6.

Prince HM, Whittaker S, Hoppe RT. How I treat mycosis fungoides and Sézary syndrome. Blood. 2009;114(20):4337-53.

Knobler E. Current management strategies for cutaneous T-cell lymphoma. Clin Dermatol. 2004;22(3):197-208.

Lundin J, Hagberg H, Repp R, Cavallin-Ståhl E, Fredén S, Juliusson G, et al. Phase 2 study of alemtuzumab (anti-CD52 monoclonal antibody) in patients with advanced mycosis fungoides/Sezary syndrome. Blood. 2003;101(11):4267-72.

Downloads

Published

2017-02-10