A study of visual evoked potentials and effect of relaxation technique in patients with migraine

Dalia A. Biswas, Meghana A. Gaikwad

Abstract


It is a cross-sectional comparative study in which comparison was done between 1) group A comprising  of 15 cases of migraine (without aura) on medication only, 2) group B comprising of 15 cases of migraine (without aura) and practicing Rajyoga meditation and deep breathing and 3) control group who were 15 age matched normal subjects.  This study was conducted in the interictal period. The most striking finding was - A decrease in P100 (ms) at post-test in both the eyes in group B, (though this finding is not significant), in contrast to group A which showed a significant increase in P100 (ms) at post-test. Both the groups showed an increase in P100-N75 (µv) & this finding was not significant in both. Multiple comparisons using Tukey test and one way ANOVA showed significant finding between groups and within groups for P100 and N145 latencies for the right eye. No such difference was seen with left eye. We conclude that Rajyoga meditation and deep breathing can be used as adjuncts to routine antimigraine therapy. We advocate the continuous practice of these interventions which might decrease the frequency of attacks & finally the elimination of this problem.


Keywords


Rajyoga meditation, Migraine, Antimigraine therapy

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References


Samhita Panda, Manjari Tripathi. Clinical profile of migraineurs in a referral centre in India. J Assoc Physicians India. 2005 Feb;53:111-5.

Gianluca Coppola, Antonio Curra, Simona Liliana Sava, Alessia Alibardi Vincenzo Parisi, Francesco Pierelli et al. Changes in visual-evoked potential habituation induced by hyperventilation in migraine. J Headache Pain. 2010;11:497-503.

Stewart WF, Lipton RB, Celentano DD, Reed ML. Prevalence of migraine in the United States. Relation to age, income, race and other socio-demographic factors. J Am Med Assoc. 1992;267:64-9.

Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 1988;8(Suppl 7):1-96.

Ottman R, Hong S, Lipton RB. Validity of family history data on severe headache and migraine. Neurol. 1993;43:1954-60.

Migraine prevention: techniques are available, but underutilized. New guidelines emphasize ways to reduce the number of migraine attacks. Duke Med Health News. 2012 Jul;18(7):6-7.

KennardC, Gawel M, Rudolph Nde M, Rose FC. Visual evoked potentials in migraine subjects. Res Clin Stud Headache. 1987;6;73-80.

Winter A. Electrophysiological studies of the visual system of people with classical migraine. In: Winter A, eds. Ph.D. thesis. Surrey, UK: University of Surrey, 1985.

Polich J, Ehlers CL, Dalassio DJ. Pattern shift visual evoked responses and EEG in migraine. Headache. 1986;26(9):451-6.

MarianiE, MoschiniV, Pastorino GC et al. Pattern reversal visual evoked potential (VEP-PR) in migraine subjects with visual aura. Headache. 1990;30(7):435-8.

Wilkins A, Nimmo-Smith I, Tait A, McManus C, Della Sala S, Tilley A et al. A neurological basis for visual discomfort. Brain. 1984;107:989-1017.

Marcus DA, Soso MJ. Migraine and stripe induced visual discomfort. Arch Neurol. 1989;46:1129-32.

Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorder, cranial neuralgias and facial pain. Cephalalgia. 1988;8(Suppl 7):1-96.

Afra J, Proietti Cecchini A, De Pasqua V, Albert A, Schoenen J. Visual evoked potentials during long periods of pattern reversal stimulation in migraine. Brain. 1998;121:233-41.

Neelam D. Sukhsohale, Mrinal S. Phatak. Effect of short term & long term Brahmakumaris Rajayoga meditation on Physiological variables. Indian J Physiol Pharmacol. 2012;56(4):388-92.

Schoenen J. Abnormal cortical information processing between migraine attacks. In: Sandler M, Ferrari M, Harnett S, eds. Migraine: Pharmacology and Genetics. 1st ed. London: Altman; 1996: 233-253.

Diener HC, Ndosi NK, Koletzki E, Langohr HD. Visual evoked potentials in migraine. In: Pfaffenrath V, Lundberg PJ, Sjaastad O, eds. Updating in Headache. 2nd ed. Berlin: Springer-Verlag; 1984: 439-465.

Khalil NM. Investigations of visual function in migraine using visual evoked potentials and visual psychological tests. In: Khalil NM, eds. PhD thesis. London: University of London; 1991.

Skuse NF, Burke D. Sequence dependent deterioration in the visual evoked potential in the absence of drowsiness. Electroencephalogr Clin neurophysiol. 1992;84:20-5.

Judit Afra, Alberto Proietti Cecchini, Victor De Pasqua, Adelin Alberta, Jean Schoenen. Visual evoked potentials during long periods of pattern - reversal stimulation in migraine. Brain. 1998;121:233-41.

Mesulam MM. Large-scale neurocognitive networks and distributed processing for attention, language and memory. Ann Neurol. 1990;28:597- 613.

Jacobs BL, Azmitia EC. Structure and function of the brain serotonin system. Physiol Rev. 1992;72:165-229.

Ferrari MD. Biochemistry of migraine. Pathol Biol (Paris). 1992;40:284-92.

Knott JR, Irwin DA. Anxiety, stress, and the contingent negative variation. Arch Gen Psychiatr. 1973; 29:538-41.

Ophoff RA, Terwindt GM, Vergouwe MN, Eijk R van, Oefner PJ, Hoffman SM et al. Familial hemiplegic migraine and episodic ataxia type 2 are caused by mutations in the Ca2+ channel gene Cacnlia4. Cell. 1996;87:543-52.

Lauritzen M. Pathophysiology of the migraine aura. The spreading depression theory. Brain. 1994;117:199-210.

Ipata A, Girelli M, Miniussi C, et al. Interhemispheric transfer of visual information in humans: the role of different callosal channels. Arch Ital Biol. 1997 Mar;135(2):169-82.

Andrew B. Evans, Selim R. Benbadis et al. Clinical utility of evoked potentials, 2014. Available at http://emedicine.medscape.com/article/1137451-overview. Accessed 18 March 2014.