Study of serum lipid profile in type 2 diabetes mellitus patients and its association with diabetic nephropathy

Authors

  • Ullasini Kolhar Department of Medicine, ESICMC and PGIMSR, Bangalore, Karnataka, India
  • Priyanka P. Department of Medicine, VIMS and RC, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20174639

Keywords:

Diabetes mellitus, Diabetic nephropathy, Lipid profile

Abstract

Background: Dyslipidaemia is highly prevalent in type 2 Diabetes mellitus patients. The role of dyslipidaemia in macrovascular complications of Diabetes have been extensively studied but its role in microvascular complications namely nephropathy is still unclear. The present study was undertaken to study the prevalence and pattern of dyslipidaemia and its association with Diabetic nephropathy (DN) in patients with type 2 DM.

Methods: 100 patients with type 2 DM attending OPD or admitted, over a period of 1 year were studied. Detailed history was taken and clinical examination was done. Serum lipid profile was studied in all patients and its association with DN was assessed.

Results: The prevalence of dyslipidaemia in DM patients in our study was 90% and there was no statistically significant difference in the prevalence among males and females. Poorly controlled diabetics had high prevalence of dyslipidaemia as compared to well controlled diabetics. The prevalence of Diabetic nephropathy in our study was 41%. There was significant association of DN with high Total Cholesterol, high Low-density lipoprotein (LDL-C) and high Triglycerides. There was no significant association of DN with High density lipoprotein (HDL-C).

Conclusions: Present study highlights the magnitude of dyslipidaemia in type2 DM patients and that there is a significant association of DN with lipid parameters. Hence patients should be managed with life style modifications with or without lipid lowering agents to achieve target lipid values along with adequate glycemic control to prevent or delay the appearance and progression of DN.

References

Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. Elsevier; 2010;87(1):4-14.

Ayodele OE, Alebiosu CO, Salako BL. Diabetic nephropathy - A review of the natural history, burden, risk factors and treatment. J Natl Med Assoc. 2004;96(11):1445-54.

Jayarama N, Reddy M, Raj SD. Prevalence and pattern of dyslipidemia in type 2 diabetes mellitus patients in a rural tertiary care centre, southern India. Glob J Med Public Health. 2012;1:24-8.

Dadhania J, Trivedi A. The Prevalence and Pattern of Dyslipidemia among Type 2 Diabetic Patients at Rural Based Hospital in Gujarat, India. 2012;22(12).

Nii D, Tagoe A, Amo-kodieh P. Type 2 diabetes mellitus influences lipid profile of diabetic patients. 2013;4(6):88-92.

Vinodmahato R, Gyawali P, Raut PP, Regmi P, Singh KP, Pandeya DR, et al. Association between glycaemic control and serum lipid profile in type 2 diabetic patients: Glycated haemoglobin as a dual biomarker. Biomed Res. 2011;22(3):375-80.

Tayde P, Borle A, Zanwar Y, Rode M, Phatak M. Glycated hemoglobin pattern and its correlation with lipid profile in type-2 diabetic males in central india. 2013;4(4).

Bamashmoos MA, Ganem Y. Diabetic Nephropathy and its Risk Factors in Type 2-Diabetic Patients in Sana ’ a City. Yemen. 2013;9(3):147-52.

Krairittichai U, Potisat S, Jongsareejit A, Sattaputh C. Prevalence and risk factors of diabetic nephropathy among Thai patients with type 2 diabetes mellitus. J Med Assoc Thail. 2011;94 Suppl 2:S1-5.

Kanakamani J, Ammini AC, Gupta N, Dwivedi SN. Prevalence of microalbuminuria among patients with type 2 diabetes mellitus--a hospital-based study from north India. Diabetes Technol Ther. 2010;12(2):161-6.

Macisaac RJ, Jerums G. Diabetic kidney disease with and without albuminuria. Curr Opin Nephrol Hypertens. 2011;20(3):246-57.

Toth PP, Simko RJ, Palli SR, Koselleck D, Quimbo R a, Cziraky MJ. The impact of serum lipids on risk for microangiopathy in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. Cardiovascular Diabetol. 2012;11(1):109.

Jenkins AJ, Lyons TJ, Zheng D, Otvos JD, Lackland DT, McGee D, et al. Lipoproteins in the DCCT/EDIC cohort: associations with diabetic nephropathy. Kidney Int. 2003;64(3):817-28.

Jisieike-Onuigbo N, Unuigbe E, Kalu O, Oguejiofor C, Onuigbo P. Prevalence of dyslipidemia among adult diabetic patients with overt diabetic nephropathy in Anambra state South-East Nigeria. Niger J Clin Pract. 2011;14(2):171-5.

Mahmood K, Aziz A. Targeting LDL Dyslipidemia for Controlling Progression of Nephropathy in Diabetic Population: A Cross Sectional Analytical Study. 2012;6(1):7-11.

Al-jameil N, Khan FA, Arjumand S, Khan MF, Tabassum H. Dyslipidemia and its correlation with type 2 diabetic patients at different stages of proteinuria . 2014;25(3):327-31.

Katore SD, Mahajan BH, Fating PM, Muddeshwar MG, Pramanik S. Atherogenic Dyslipidemia in Diabetic Nephropathy. 2014;10(3):472-5.

Agrawal RP, Sharma P, Pal M, Kochar A, Kochar DK. Magnitude of dyslipedemia and its association with micro and macro vascular complications in type 2 diabetes: a hospital based study from Bikaner (Northwest India). Diabetes Res Clin Pr. 2006;73(2):211-4.

Downloads

Published

2017-11-22

Issue

Section

Original Research Articles